ArticleFrontiers in aging neuroscience2020
Afferent and Efferent Visual Markers of Alzheimer's Disease: A Review and Update in Early Stage Disease.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- The Association between Saccadic Eye Movement Parameters and Mild Cognitive Impairment: The Nagahama Study.Ophthalmology science · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Advances in ocular motor and pupil biomarkers for neurological disorders.Brain communications · 2026Review
- Tablet-Based Assessment of Picture Naming in Prodromal Alzheimer's Disease: An Accessible and Effective Tool for Distinguishing Mild Cognitive Impairment from Normal Aging.Dementia and geriatric cognitive disorders · 2026Article
- Time/Movement Estimation and Mental Rotation Tasks as Early Cognitive Markers in Alzheimer's Disease.Brain and behavior · 2025Article
- Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Correlating retinal and choroidal vascular parameters with volumetric MRI in Alzheimer's disease and amnestic mild cognitive impairment.BMC ophthalmology · 2025Article
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer's Disease.The Journal of infectious diseases · 2024Review
- Visual search in Alzheimer's disease and amnestic mild cognitive impairment: An eye-tracking study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The bidirectional relationship between subjective visual function and domain-specific cognition in cognitively unimpaired older adults and adults with mild cognitive impairment.Frontiers in aging neuroscience · 2024Article
- Characterising cerebrovascular reactivity and the pupillary light response-a comparative study.Frontiers in physiology · 2024Article
- Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
- Vision as a piece of the head trauma puzzle.Eye (London, England) · 2023Review
- Early visual alterations in individuals at-risk of Alzheimer's disease: a multidisciplinary approach.Alzheimer's research & therapy · 2023Article
- Characterization of the angular gyrus in an older adult population: a multimodal multilevel approach.Brain structure & function · 2023Article
- Automated High-Definition MRI Processing Routine Robustly Detects Longitudinal Morphometry Changes in Alzheimer's Disease Patients.Frontiers in aging neuroscience · 2022Article
- Current and Future Trends in Biomarkers for the Early Detection of Alzheimer's Disease in Asia: Expert Opinion.Journal of Alzheimer's disease reports · 2022Review
- Improving Our Understanding of Driving Changes in Preclinical and Early Symptomatic Alzheimer's Disease: The Role of Naturalistic Driving Studies.Journal of Alzheimer's disease reports · 2022Review
- Analysis of pupillometer results according to disease stage in patients with Parkinson's disease.Scientific reports · 2021Article
Corrections and comments
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3 authors.
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Abstract
Vision, which requires extensive neural involvement, is often impaired in Alzheimer's disease (AD). Over the last few decades, accumulating evidence has shown that various visual functions and structures are compromised in Alzheimer's dementia and when measured can detect those with dementia from those with normal aging. These visual changes involve both the afferent and efferent parts of the visual system, which correspond to the sensory and eye movement aspects of vision, respectively. There are fewer, but a growing number of studies, that focus on the detection of predementia stages. Visual biomarkers that detect these stages are paramount in the development of successful disease-modifying therapies by identifying appropriate research participants and in identifying those who would receive future therapies. This review provides a summary and update on common afferent and efferent visual markers of AD with a focus on mild cognitive impairment (MCI) and preclinical disease detection. We further propose future directions in this area. Given the ease of performing visual tests, the accessibility of the eye, and advances in ocular technology, visual measures have the potential to be effective, practical, and non-invasive biomarkers of AD.
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