ArticleEJIFCC2020
Extra-Analytical Clinical Laboratory Errors in Africa: A Systematic Review and Meta-Analysis.
Article in EJIFCC, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Best practices in sample management & pre-analytical quality control: overcoming challenges in resource-limited laboratory settings.Tropical medicine and health · 2026Review
- Assessment of Clinical Hematology Laboratory Performance Using Sigma Metrics and Associated Factors in Total Testing Process at the Dessie Comprehensive Specialized Hospital, Northeast, Ethiopia: A Cross-Sectional Study.Health science reports · 2026Article
- Performance Analysis of Clinical Chemistry Laboratory Using Sigma Metrics in the Total Testing Process at Dessie Comprehensive Specialized Hospital, Ethiopia.Journal of clinical laboratory analysis · 2025Article
- Assessment of Hematology Laboratory Specimen Rejection Rate and Associated Factors at Northwest, Ethiopia.Health science reports · 2025Article
- Enhancing Diagnostic and Patient Safety in Healthcare Systems: Key Insights from the World Patient Safety Day 2024 Commemoration in Uganda.Drug, healthcare and patient safety · 2025Review
- Assessment of hematology laboratory performance in the total testing process using quality indicators and sigma metrics in the northwest of Ethiopia: A cross-sectional study.Health science reports · 2024Article
- Blood specimen rejection rate in clinical laboratory: A systematic review and meta-analysis.Practical laboratory medicine · 2023Review
- Development of a quality indicator set to measure and improve quality of ICU care in low- and middle-income countries.Intensive care medicine · 2022Article
- The incidence rate and influence factors of hemolysis, lipemia, icterus in fasting serum biochemistry specimens.PloS one · 2022Article
- Article
- Interferences in Clinical Chemistry: A Neglected Cause of Laboratory Errors in Medical Practice in resource constrained settings.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical laboratory testing is a highly complex process involving a different procedure. Laboratory errors may occur at any stage of the test process, but most errors occur during extra-analytical phases. The magnitude of clinical laboratory errors, in particular extra-analytical errors, was inconsistent in different studies.
methodsA systematic review and meta-analysis were conducted based on the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The extracted data were entered into a Microsoft Excel spreadsheet and transferred to STATA version 11 for the analysis. Random effect model was used to estimate pooled prevalence of extra-clinical laboratory errors and I
resultsA total of 1,381 studies were searched, 19 were included in this systematic review and meta-analysis. A total of 621,507 pre-analytical and 51,859 post-analytical outcomes of quality indicators were reported. A total of 145,515 samples were assessed for rejection and 62,513 laboratory requests were evaluated for incompleteness. The pooled prevalence of pre-analytical and post-analytical errors in Africa was 17.5% (95% Cl: 11.55, 23.45) and 10.99% (95% Cl: 5.30, 16.67) respectively. The pooled prevalence of specimen rejection and laboratory request forms incompleteness in Africa was 2.0% (95% Cl: 0.86, 3.14) and 7.55% (95% Cl: 2.30, 12.80) respectively.
conclusionThe study found high prevalence of pre- and of post-analytical clinical laboratory errors in Africa. In addition, the study showed that the standard completion of the laboratory request forms was poor and there were significant numbers of specimen rejections. Therefore, clinical laboratories should ensure compliance with standard operating procedures, the laboratory information system, the cooperation of the entire staff and the targeted training of sample collectors.
Indexed as
Identifiers
33061876PMC7545128What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.