Evidence map›Paper›PMID 33061822›Full record

ArticleMediators of inflammation2020

Elevated Circulating Fetuin-B Levels Are Associated with Insulin Resistance and Reduced by GLP-1RA in Newly Diagnosed PCOS Women.

Mani Mokou, Shan Yang, Bin Zhan, Shan Geng, Kejia Li, Mengliu Yang, Gangyi Yang, Wuquan Deng, Hua Liu, Dongfang Liu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Review
  3. The Role and Mechanism of Incretins in Gynaecologic Diseases.Endocrinology, diabetes & metabolism · 2026
    Review
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  11. Cord Blood Fetuin-B, Fetal Growth Factors, and Lipids in Gestational Diabetes Mellitus.The Journal of clinical endocrinology and metabolism · 2025
    Article
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Mani MokouKey Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, 400016 Chongqing, China.ORCID https://orcid.org/0000-0001-8609-9061
Shan YangDepartment of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.ORCID https://orcid.org/0000-0003-0583-3637
Bin ZhanThe Thirteenth People's Hospital of Chongqing, Chongqing 400016, China.
Shan GengThe Thirteenth People's Hospital of Chongqing, Chongqing 400016, China.ORCID https://orcid.org/0000-0003-0838-4726
Kejia LiDepartment of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Mengliu YangDepartment of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Gangyi YangDepartment of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Wuquan DengDepartment of Endocrinology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing 400014, China.ORCID https://orcid.org/0000-0002-9883-5051
Hua LiuDepartment of Pediatrics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA.
Dongfang LiuDepartment of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Zhiming ZhuDepartment of Hypertension and Endocrinology, Daping Hospital, Army Medical University, Chongqing Institute of Hypertension, Chongqing 400010, China.
Ling LiKey Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, 400016 Chongqing, China.ORCID https://orcid.org/0000-0002-0087-3034
Dalian Medical University · CNChongqing Medical University · CNThird People 's Hospital of Chongqing · CNArmy Medical University · CNChongqing University · CNState Street (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have suggested that Fetuin-B seems to be a secreted adipokine related to metabolic diseases. However, the results have been inconsistent. Here, our objective is to investigate the changes in circulating Fetuin-B levels in women with polycystic ovary syndrome (PCOS) and analyze the association of Fetuin-B and insulin resistance (IR).

methodsThe current study is comprised of a cross-sectional study and a series of interventional studies. Oral glucose tolerance test (OGTT) and euglycemic-hyperinsulinemic clamp (EHC) were engaged to assess glucose tolerance and insulin sensitivity. Serum Fetuin-B levels were determined by ELISA.

resultsSerum Fetuin-B and TNF-

conclusionOur results indicate that Fetuin-B may be a biomarker of IR in individuals with PCOS. This trial is registered with ChiCTR-IIR-16007901.

Indexed as

AdultBiomarkersBlood GlucoseCholesterol, LDLCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayEstradiolFemaleFetuin-BGlucose Tolerance TestHumansInsulin ResistanceLuteinizing HormonePolycystic Ovary SyndromeProgesteroneProlactinBiomarkersBlood GlucoseCholesterol, LDLEstradiolFetuin-BLuteinizing HormoneProgesteroneProlactinTriglyceridesTumor Necrosis Factor-alpha

Identifiers

PMID33061822
PMCPMC7545451
OpenAlexW3090110742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.