Evidence map›Paper›PMID 33061818›Full record

ArticleInternational journal of biological sciences2020

Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level.

Peijian Zhang, Erlinda The, Balachandar Nedumaran, Lihua Ao, Michael J Jarrett, Dingli Xu, David A Fullerton, Xianzhong Meng

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Myeloid TLR2 signaling amplifies immunopathology in influenza-infected murine neonates.American journal of respiratory cell and molecular biology · 2026
    Article
  3. Article
  4. Article
  5. Macrophages as key modulators of calcific aortic valve disease.Frontiers in cardiovascular medicine · 2025
    Review
  6. Review
  7. Saponins ofMolecules (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Article
  10. Monocytes augment inflammatory responses in human aortic valve interstitial cells via βInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Peijian ZhangDepartment of Surgery, University of Colorado Denver, Aurora, CO 80045.
Erlinda TheDepartment of Surgery, University of Colorado Denver, Aurora, CO 80045.
Balachandar NedumaranDepartment of Surgery, University of Colorado Denver, Aurora, CO 80045.
Lihua AoDepartment of Surgery, University of Colorado Denver, Aurora, CO 80045.
Michael J JarrettDepartment of Surgery, University of Colorado Denver, Aurora, CO 80045.
Dingli XuDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
David A FullertonDepartment of Surgery, University of Colorado Denver, Aurora, CO 80045.
Xianzhong MengDepartment of Surgery, University of Colorado Denver, Aurora, CO 80045.
University of Colorado Denver · USNanfang Hospital · CN

Funding

Role of inflammatory response in aortic valve lesionsR01HL106582 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MENG, XIANZHONG · 2011 to 2020
$3.8M
Suppression of AVIC inflammosteogenesis for prevention of CAVD progressionR01HL121776 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MENG, XIANZHONG · 2015 to 2023
$3.6M
NHLBI NIH HHS R01 HL106582NHLBI NIH HHS R01 HL121776
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Aortic ValveAortic Valve StenosisMonocytesToll-Like Receptor 2Cells, CulturedHumansUp-RegulationTLR2 protein, humanToll-Like Receptor 2adhesion moleculesAortic valvesinflammationmonocytesToll-like receptor

Identifiers

PMID33061818
PMCPMC7545700
OpenAlexW3092518313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.