ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2020
Joint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 29 citations in OpenAlex.
- Associations of Geriatric Nutritional Risk Index and Prognostic Nutritional Index With All-Cause and Cardiovascular Mortality in DKD: NHANES 1999-2018.International journal of endocrinology · 2026Article
- Role of hyperhomocysteinemia in atherosclerosis: from bench to bedside.Annals of medicine · 2025Review
- Burden of lower-limb peripheral arterial disease in China and its comparison with global estimates, 1990-2021: analysis of global burden of disease (GBD) data by sex and age group.BMC cardiovascular disorders · 2025Article
- Association of plasma homocysteine with peripheral arterial disease in the hypertensive adults: A cross-sectional study.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Association between geriatric nutritional risk index and depression prevalence in the elderly population in NHANES.BMC public health · 2024Article
- Association of Blood Heavy Metal Exposure with Atherosclerotic Cardiovascular Disease (ASCVD) Among White Adults: Evidence from NHANES 1999-2018.Biological trace element research · 2023Article
- Intermediate-Term Prognostic Value of Homocysteine in Acute Coronary Syndrome Complicated with or without Hypertension: A Multicenter Observational Cohort Study.Reviews in cardiovascular medicine · 2023Article
- Additive effect between homocysteine and low-density-lipoprotein cholesterol upon incidence of novel carotid plaque formation: data from a Chinese community-based cohort.BMC cardiovascular disorders · 2023Article
- Circulating level of homocysteine contributes to diabetic retinopathy associated with dysregulated lipid profile and impaired kidney function in patients with type 2 diabetes mellitus.Eye (London, England) · 2023Article
- Relationship between serum homocysteine, fibrinogen, lipoprotein-a level, and peripheral arterial disease: a dose-response meta-analysis.European journal of medical research · 2022Review
- Association between serum Klotho levels and the prevalence of diabetes among adults in the United States.Frontiers in endocrinology · 2022Article
- Association of Plasma Bilirubin Levels With Peripheral Arterial Disease in Chinese Hypertensive Patients: New Insight on Sex Differences.Frontiers in physiology · 2022Article
- Iron Metabolism Markers and Lower Extremity Arterial Disease in People with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Association between migraine and cardiovascular disease: A cross-sectional study.Frontiers in cardiovascular medicine · 2022Article
- Assessment of Peripheral Arterial Disease among Type 2 Diabetes Patients in Calabar, Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHyperhomocysteinemia is an independent risk factor for cardio- and cerebrovascular diseases. However, the relationship between plasma homocysteine (Hcy) concentration and peripheral arterial disease (PAD) has not been completely characterized. The aim of the present study was to determine the relationship between plasma Hcy concentration and new-onset PAD and to assess the effects of combinations of Hcy and traditional cardiovascular risk factors. PATIENTS AND
methodsWe conducted a prospective community-based cohort study of 3119 Chinese participants who did not have PAD at baseline, with a median follow-up period of 2.30 years. We used multivariate logistic regression models to evaluate the relationship between high Hcy (≥10µmol/L) and new-onset PAD. The effects of combinations of high Hcy and traditional cardiovascular risk factors were assessed using logistic regression analysis.
resultsAfter adjustment for 14 covariates, high Hcy concentration was significantly associated with new-onset PAD (odds ratio [OR]=2.08, 95% confidence interval [CI]: 1.08-4.03,
conclusionHigh plasma Hcy concentration independently predicts the incidence of PAD. Furthermore, there is a joint effect of high Hcy concentration and traditional cardiovascular risk factors such as smoking, diabetes and aging on the incidence of PAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.