Evidence map›Paper›PMID 33061384›Full record

ArticleInternational journal of nanomedicine2020

Species-Specific in vitro and in vivo Evaluation of Toxicity of Silver Nanoparticles Stabilized with Gum Arabic Protein.

Joana S Maziero, Velaphi C Thipe, Sizue O Rogero, Adriana K Cavalcante, Kelme C Damasceno, Matheus B Ormenio, Gisela A Martini, Jorge G S Batista, William Viveiros, Kavita K Katti and 7 more

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
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  5. Green Nanotechnology ofNanotechnology, science and applications · 2023
    Article
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  8. Review
  9. pH ResponsiveInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Joana S MazieroLaboratório de Ecotoxicologia, Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares (IPEN), Comissão Nacional de Energia Nuclear- IPEN/CNEN-SP, São Paulo, SP, Brazil.
Velaphi C ThipeLaboratório de Ecotoxicologia, Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares (IPEN), Comissão Nacional de Energia Nuclear- IPEN/CNEN-SP, São Paulo, SP, Brazil.ORCID 0000-0003-4426-6567
Sizue O RogeroLaboratório de Ecotoxicologia, Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares (IPEN), Comissão Nacional de Energia Nuclear- IPEN/CNEN-SP, São Paulo, SP, Brazil.ORCID 0000-0003-3396-6277
Adriana K CavalcanteLaboratório de Ecotoxicologia, Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares (IPEN), Comissão Nacional de Energia Nuclear- IPEN/CNEN-SP, São Paulo, SP, Brazil.
Kelme C DamascenoLaboratório de Ecotoxicologia, Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares (IPEN), Comissão Nacional de Energia Nuclear- IPEN/CNEN-SP, São Paulo, SP, Brazil.
Matheus B OrmenioLaboratório de Ecotoxicologia, Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares (IPEN), Comissão Nacional de Energia Nuclear- IPEN/CNEN-SP, São Paulo, SP, Brazil.ORCID 0000-0003-2951-709X
Gisela A MartiniLaboratório de Ecotoxicologia, Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares (IPEN), Comissão Nacional de Energia Nuclear- IPEN/CNEN-SP, São Paulo, SP, Brazil.
Jorge G S BatistaLaboratório de Biomateriais Poliméricos e Nanotheranóstica, Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares (IPEN), Comissão Nacional de Energia Nuclear- IPEN/CNEN-SP, São Paulo, SP, Brazil.ORCID 0000-0003-1172-8630
William ViveirosLaboratório de Ecotoxicologia, Companhia Ambiental do Estado de São Paulo (CETESB), São Paulo, SP, Brazil.ORCID 0000-0001-6052-2669
Kavita K KattiInstitute of Green Nanotechnology, Department of Radiology, University of Missouri Columbia, Columbia, MO, USA.
Alice Raphael KarikacheryInstitute of Green Nanotechnology, Department of Radiology, University of Missouri Columbia, Columbia, MO, USA.
DarshaKumar Dhurvas MohandossDhanvantari Nano Ayushadi Pvt Ltd, Chennai, Tamil Nadu, India.
Rashmi DarshaKumar DhurvasDhanvantari Nano Ayushadi Pvt Ltd, Chennai, Tamil Nadu, India.
Mohanavelu NappinnaiDhanvantari Nano Ayushadi Pvt Ltd, Chennai, Tamil Nadu, India.
José R RogeroLaboratório de Biomateriais Poliméricos e Nanotheranóstica, Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares (IPEN), Comissão Nacional de Energia Nuclear- IPEN/CNEN-SP, São Paulo, SP, Brazil.
Ademar B LugãoLaboratório de Ecotoxicologia, Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares (IPEN), Comissão Nacional de Energia Nuclear- IPEN/CNEN-SP, São Paulo, SP, Brazil.
Kattesh V KattiInstitute of Green Nanotechnology, Department of Radiology, University of Missouri Columbia, Columbia, MO, USA.ORCID 0000-0003-4171-7051
Instituto de Pesquisas Energéticas e Nucleares · BRDhanvantari Ayurveda College Hospital and Research Centre · INUniversity of Missouri · USCompanhia Energética de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe report, herein, in vitro, and in vivo toxicity evaluation of silver nanoparticles stabilized with gum arabic protein (AgNP-GP) in PURPOSE: The objective of this investigation was to evaluate in vitro and in vivo toxicity of silver nanoparticles stabilized with gum arabic protein (AgNP-GP), in multispecies due to the recognition that toxicity evaluations beyond a single species reflect the environmental realism. In the present study, AgNP-GP was synthesized through the reduction of silver salt using the tri-alanine-phosphine peptide (commonly referred to as "Katti Peptide") and stabilized using gum arabic protein.

methodsIn vitro cytotoxicity tests were performed according to ISO 10993-5 protocols to assess cytotoxicity index (IC

resultsAgNP-GP nanoparticles were characterized through UV (405 nm), core size (20±5 nm through TEM), hydrodynamic size (70-80 nm), Zeta (ζ) potential (- 26 mV) using DLS and Powder X ray diffraction (PXRD) and EDS. PXRD showed pattern consistent with the Ag (1 1 1) peak. EC

conclusionThe non-toxicity of AgNP-GP in rats offers a myriad of applications of AgNP-GP in health and hygiene for use as antibiotics, antimicrobial and antifungal agents.

Indexed as

AnimalsDaphniaEcotoxicologyEmbryo, NonmammalianFemaleGum ArabicLethal Dose 50MaleMetal NanoparticlesPlant ProteinsRats, Sprague-DawleySilverSpecies SpecificityWater Pollutants, ChemicalZebrafishGum ArabicPlant ProteinsSilverWater Pollutants, ChemicalcytotoxicityDaphnia similisecotoxicitynanoparticlesSprague Dawleyzebrafish

Identifiers

PMID33061384
PMCPMC7537814
OpenAlexW3091315311

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.