Evidence map›Paper›PMID 33061029›Full record

ArticleIndian journal of thoracic and cardiovascular surgery2019

Effect of goal-directed therapy on post-operative neutrophil gelatinase-associated lipocalin profile in patients undergoing on-pump coronary artery surgery.

Poonam Malhotra Kapoor, Ameya Karanjkar, Rohan Magoon, Sameer Taneja, Sambhunath Das, Vishwas Malik, Ujjwal Kumar Chowdhury, Vajala Ravi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of thoracic and cardiovascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Intraoperative Goal-Directed Perfusion in Cardiac Surgery with Cardiopulmonary Bypass: The Roles of Delivery Oxygen Index and Cardiac Index.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2024
    Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Poonam Malhotra KapoorDepartment of Cardiac Anaesthesia, Cardiothoracic Centre, CNC, All India Institute of Medical Sciences, Room No. 8, 7th Floor, Cardiothoracic Centre, Cardiothoracic Centre, Ansari Nagar, New Delhi, 110029 India.ORCID 0000-0003-3102-5043
Ameya KaranjkarDepartment of Cardiac Anaesthesia, Cardiothoracic Centre, CNC, All India Institute of Medical Sciences, Room No. 8, 7th Floor, Cardiothoracic Centre, Cardiothoracic Centre, Ansari Nagar, New Delhi, 110029 India.
Rohan MagoonDepartment of Cardiac Anaesthesia, Cardiothoracic Centre, CNC, All India Institute of Medical Sciences, Room No. 8, 7th Floor, Cardiothoracic Centre, Cardiothoracic Centre, Ansari Nagar, New Delhi, 110029 India.
Sameer TanejaDepartment of Cardiac Anaesthesia, Cardiothoracic Centre, CNC, All India Institute of Medical Sciences, Room No. 8, 7th Floor, Cardiothoracic Centre, Cardiothoracic Centre, Ansari Nagar, New Delhi, 110029 India.
Sambhunath DasDepartment of Cardiac Anaesthesia, Cardiothoracic Centre, CNC, All India Institute of Medical Sciences, Room No. 8, 7th Floor, Cardiothoracic Centre, Cardiothoracic Centre, Ansari Nagar, New Delhi, 110029 India.
Vishwas MalikDepartment of Cardiac Anaesthesia, Cardiothoracic Centre, CNC, All India Institute of Medical Sciences, Room No. 8, 7th Floor, Cardiothoracic Centre, Cardiothoracic Centre, Ansari Nagar, New Delhi, 110029 India.
Ujjwal Kumar ChowdhuryCardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, Cardiothoracic Centre, CNC, Ansari Nagar, New Delhi, 110029 India.
Vajala RaviLady Shri Ram College, University of Delhi, New Delhi, 110024 India.
All India Institute of Medical Sciences · INUniversity of Delhi · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker of acute kidney injury (AKI). Goal-directed therapy (GDT) in on-pump coronary artery bypass grafting (CABG) has been associated with lower post-operative NGAL levels in recent studies. The present study aimed at comparing plasma (P) and urinary (U)-NGAL levels following the use of GDT versus conventional haemodynamic therapy (CT) in patients undergoing on-pump CABG.

methodsA prospective randomised controlled study conducted in a single university hospital. A total of 54 patients in the GDT group and 56 patients in CT group after exclusions.

resultsU-NGAL was significantly lower immediately post-surgery (

conclusionsHaemodynamic optimisation with GDT prevents further renal insult initiated with the inflammatory activation with cardiopulmonary bypass (CPB), as evidenced by lower post-operative U-NGAL levels.

Indexed as

Acute kidney injuryCardiopulmonary bypassGoal-directed therapy

Identifiers

PMID33061029
PMCPMC7525641
OpenAlexW2903743059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.