Evidence map›Paper›PMID 33060830›Full record

ReviewEye (London, England)2021

Aqueous humour outflow imaging: seeing is believing.

Jong Yeon Lee, Goichi Akiyama, Sindhu Saraswathy, Xiaobin Xie, Xiaojing Pan, Young-Kwon Hong, Alex S Huang

Open access · bronzeAbstract readReview
In one paragraph

Review in Eye (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Jong Yeon LeeDoheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Goichi AkiyamaDoheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Sindhu SaraswathyDoheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Xiaobin XieDoheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Xiaojing PanDoheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Young-Kwon HongDepartment of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Alex S HuangDoheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California, USA. Ahuang@Doheny.org.ORCID http://orcid.org/0000-0001-9024-9608
University of California, Los Angeles · USJikei University School of Medicine · JPUniversity of Southern California · US

Funding

Structural and Functional Studies of the Uterine LymphaticsR01HL141857 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Young-Kwon Hong · 2018 to 2026
$3.6M
Dynamic Variable Aqueous Humor Outflow and Glaucoma Therapies in the Human EyeR01EY030501 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Alex Huang, Hao F Zhang · 2020 to 2026
$3.5M
Prox1 Phosphorylation in Lymphatic Development and FunctionR01DK114645 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HONG, YOUNG-KWON · 2018 to 2022
$2.1M
Flow Dependent Development and Maintenance of Schlemm's CanalR21EY026260 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HONG, YOUNG-KWON · 2016 to 2017
$454k
Japan Society for the Promotion of Science London (JSPS London) JP18K16972NEI NIH HHS R01 EY030501NEI NIH HHS R21 EY026260NHLBI NIH HHS R01 HL141857NIDDK NIH HHS R01 DK114645
6 · The paper itself

Abstract

Elevated intraocular pressure (IOP) is the primary risk factor for blindness in glaucoma. IOP is determined by many factors including aqueous humour production and aqueous humour outflow (AHO), where AHO disturbance represents the primary cause of increased IOP. With the recent development of new IOP lowering drugs and Minimally Invasive Glaucoma Surgeries (MIGS), renewed interest has arisen in shedding light on not only how but where AHO is occurring for the trabecular/conventional, uveoscleral/unconventional, and subconjunctival outflow pathways. Historical studies critical to understanding outflow anatomy will be presented, leading to the development of modern imaging methods. New biological behaviours uncovered by modern imaging methods will be discussed with relevance to glaucoma therapies emphasized.

Indexed as

Aqueous HumorGlaucomaHumansIntraocular PressureMinimally Invasive Surgical Procedures

Identifiers

PMID33060830
PMCPMC7852535
OpenAlexW3092691461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.