Evidence map›Paper›PMID 33060780›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2021

Concentrating human milk: an innovative point-of-care device designed to increase human milk feeding options for preterm infants.

Elizabeth R Schinkel, Elizabeth R Nelson, Bridget E Young, Robin M Bernstein, Sarah N Taylor, Laura D Brown, William W Hay, Kitty J Brown, Jessica Prenni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Point-of-care human milk concentration by passive osmosis: comprehensive analysis of fresh human milk samples.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizabeth R SchinkelMother's Milk Is Best, Inc., Tyngsborough, MA, USA. beth@mothersmilkisbest.com.ORCID http://orcid.org/0000-0002-0002-3056
Elizabeth R NelsonMother's Milk Is Best, Inc., Tyngsborough, MA, USA.
Bridget E YoungDivision of Pediatrics, Allergy and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-3257-8179
Robin M BernsteinDepartment of Anthropology and Institute of Behavioral Science, University of Colorado, Boulder, CO, USA.ORCID http://orcid.org/0000-0001-8805-7527
Sarah N TaylorDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-6948-8329
Laura D BrownPerinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
William W HayUniversity of Colorado (Retired), Denver, CO, USA.
Kitty J BrownProteomics and Metabolomics Facility, Colorado State University, Fort Collins, CO, USA.
Jessica PrenniProteomics and Metabolomics Facility, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0002-0337-8450

Funding

Regulation of Fetal Skeletal Muscle Growth in IUGRR01HD079404 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Laura Davidson Brown · 2015 to 2026
$4.7M
UV-visible HPLC with PCX Pinnacle post column reaction moduleS10OD023553 · OD · UNIVERSITY OF COLORADO DENVER · PI BROWN, LAURA DAVIDSON · 2017 to 2017
$98k
NICHD NIH HHS R01 HD079404NIH HHS S10 OD023553
6 · The paper itself

Abstract

objectiveThe purpose of this study was to determine whether a point-of-care osmotic device concentrates important human milk (HM) nutrients to support feeding neonates requiring high-nutrient, low-volume feedings. STUDY

designRaw and pasteurized HM samples were concentrated to determine the effects of time and temperature on concentration. Concentrated samples were compared with matched baseline samples to measure changes in selected nutrient concentrations. Furthermore, changes in concentration of certain bioactive components of raw milk samples were measured.

resultThe device significantly increased the concentrations of the majority of the measured nutrient and bioactive levels (p < 0.05). Increasing temperature of HM from 4 to 37 °C increased the concentration rate >30%. In all cases, the concentration rate of pasteurized HM was greater than that of raw HM.

conclusionsThe osmotic concentration of HM is a promising option for neonatal nutrition. Further studies are needed to establish an evidence base for the practical applications of this point-of-care device.

Indexed as

Milk, HumanPoint-of-Care SystemsHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaInfant, PrematureNutrientsNutrients

Identifiers

PMID33060780
PMCPMC9848740

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.