Evidence map›Paper›PMID 33060734›Full record

ArticleScientific reports2020

Causal associations between urinary sodium with body mass, shape and composition: a Mendelian randomization study.

Qi Feng, Shuai Yuan, Qian Yang, Yingchang Lu, Ruth J F Loos, Gloria H Y Li, Yue Fei, Man Fung Tsoi, Ching Lung Cheung, Bernard M Y Cheung

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Qi FengDepartment of Medicine, LKS Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, China. ermadake@gmail.com.
Shuai YuanUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Qian YangMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Yingchang LuVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gloria H Y LiDepartment of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Yue FeiDepartment of Medicine, LKS Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, China.
Man Fung TsoiDepartment of Medicine, LKS Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, China.
Ching Lung CheungDepartment of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Bernard M Y CheungDepartment of Medicine, LKS Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, China. mycheung@hku.hk.
University of Hong Kong · HKIcahn School of Medicine at Mount Sinai · USKarolinska Institutet · SEMedical Research Council · GBVanderbilt University Medical Center · US

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
NIDDK NIH HHS P30 DK020541
6 · The paper itself

Abstract

Observational studies have found associations between urinary sodium (UNa) with obesity, body shape and composition; but the findings may be biased by residual confounding. The objective of this two-sample Mendelian randomization (MR) study was to analyze their causal associations in both sex-combined and sex-specific models. Genome-wide association studies of UNa, body mass index (BMI), BMI-adjusted waist-to-hip ratio (WHR), body fat (BF) percentage and estimated glomerular filtration rate (eGFR) were identified. We initially extracted fifty SNPs associated with UNa at significance level of 5 × 10

Indexed as

Body CompositionBody Mass IndexCausalityFemaleGenome-Wide Association StudyGlomerular Filtration RateHumansMaleMendelian Randomization AnalysisObesityPhenotypePolymorphism, Single NucleotideRisk FactorsSodiumWaist-Hip RatioSodium

Identifiers

PMID33060734
PMCPMC7562909
OpenAlexW3092890328

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.