ArticleScientific reports2020
Mechano-chemistry of human femoral diaphysis revealed by correlative Brillouin-Raman microspectroscopy.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Effect of Alginate Coatings on Hydroxyapatite/β-Tricalcium Phosphate Scaffold Behavior.Journal of functional biomaterials · 2026Article
- Article
- Exploring the biomechanical complexity of glioblastoma spheroids and organoids with co-localized Brillouin and Raman microspectroscopy.Biochemistry and biophysics reports · 2025Article
- Silver Nanoparticles and Simvastatin-Loaded PLGA-Coated Hydroxyapatite/Calcium Carbonate Scaffolds.Nanomaterials (Basel, Switzerland) · 2024Article
- Birefringence-induced phase delay enables Brillouin mechanical imaging in turbid media.Nature communications · 2024Article
- Brillouin microscopy.Nature reviews. Methods primers · 2024Article
- Long-Term Fate and Efficacy of a Biomimetic (Sr)-Apatite-Coated Carbon Patch Used for Bone Reconstruction.Journal of functional biomaterials · 2023Article
- Brillouin-Raman micro-spectroscopy and machine learning techniques to classify osteoarthritic lesions in the human articular cartilage.Scientific reports · 2023Article
- Microscale mechanochemical characterization of drying oil films by in situ correlative Brillouin and Raman spectroscopy.Science advances · 2022Article
- Correlation of biomechanics and cancer cell phenotype by combined Brillouin and Raman spectroscopy of U87-MG glioblastoma cells.Journal of the Royal Society, Interface · 2022Article
- Non-contact elastography methods in mechanobiology: a point of view.European biophysics journal : EBJ · 2022Review
- Brillouin-Raman microspectroscopy for the morpho-mechanical imaging of human lamellar bone.Journal of the Royal Society, Interface · 2022Article
- Brillouin and Raman Micro-Spectroscopy: A Tool for Micro-Mechanical and Structural Characterization of Cortical and Trabecular Bone Tissues.Materials (Basel, Switzerland) · 2021Article
- Applications of Vibrational Spectroscopy for Analysis of Connective Tissues.Molecules (Basel, Switzerland) · 2021Review
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Authors and funding
6 authors.
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Abstract
Brillouin-Raman microspectroscopy is presented as an innovative label-free all-optical investigation approachable to characterize the chemical composition and the mechanical properties of human tissues at micrometric resolution. Brillouin maps unveil mechanical heterogeneities in a human femoral diaphysis, showing a ubiquitous co-existence of hard and soft components, even in the most compact sections. The novel correlative analysis of Brillouin and Raman maps shows that the relative intensity of Brillouin peaks is a good proxy for the fraction of mineralized fibers and that the stiffness (longitudinal elastic modulus) of the hard component is linearly dependent on the hydroxyapatite concentration. For the soft component, a gradient of composition is found, ranging from an abundance of proteins in the more compact, external, bone to abundance of lipids, carotenoids, and heme groups approaching the trabecular, inner, part of the diaphysis. This work unveils the strong potential of correlative mechano-chemical characterization of human tissues at a micrometric resolution for both fundamental and translational research.
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