ArticleScientific reports2020
In vivo measurement of shear modulus of the human cornea using optical coherence elastography.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ex vivo, in vivo and in silico studies of corneal biomechanics: a systematic review.Physical and engineering sciences in medicine · 2024Pooled it
- Super-resolution wave-dispersion analysis in optical coherence elastography using multiple signal classification (MUSIC).Biomedical optics express · 2026Article
- Air-Coupled Ultrasonic Optical Coherence Elastography Reveals Protocol-Dependent Corneal Stiffening in Epi-On and Epi-Off Riboflavin Crosslinking.Translational vision science & technology · 2026Article
- In vivo elastography of the human retina using light-evoked intrinsic actuation.bioRxiv : the preprint server for biology · 2026Article
- Evaluation of Changes in Ocular Tissue Elasticity Before and After Trabeculectomy Using Shear Wave Elastography.Journal of clinical medicine · 2026Article
- Optical coherence elastography detects increased corneal stiffness in nonhuman primates with experimental glaucoma.Journal of biomedical optics · 2025Article
- Shear Wave Optical Coherence Elastography and Structural Analysis of the Postnatal Mouse Cornea through Development.Journal of biophotonics · 2025Article
- Asynchronous optical coherence elastography and directional phase gradient analysis.Journal of biomedical optics · 2025Article
- A Method for Visualizing Corneal Dynamics Through Pixel Intensity Tracking.Translational vision science & technology · 2025Article
- Optical Coherence Elastography Measures Mechanical Tension in the Lens and Capsule.Acta biomaterialia · 2025Article
- A-scan sequence transformers for palpation with optical coherence elastography.Biomedical optics express · 2025Article
- Ultrafast line-field holographic elastography with single excitation for corneal biomechanical characterization.Biomedical optics express · 2025Article
- PS-OCT imaging of the anterior segment under different eyeball rotations.Biomedical optics express · 2025Article
- Analysis wave speed of optic nerve and optic nerve head for assessing normal tension glaucoma by using vibro-elastography technique.Clinical biomechanics (Bristol, Avon) · 2025Article
- Determinants of Human Corneal Mechanical Wave Dispersion for In Vivo Optical Coherence Elastography.Translational vision science & technology · 2025Article
- The Contribution of the Limbus and Collagen Fibrils to Corneal Biomechanical Properties: Estimation of the Low-Strain In Vivo Elastic Modulus and Tissue Strain.Biomimetics (Basel, Switzerland) · 2024Article
- In-vivo high-frequency quantitative ultrasound-derived parameters of the anterior sclera correlated with level of myopia and presence of staphyloma.Clinical & experimental ophthalmology · 2024Article
- A unique and biocompatible corneal collagen crosslinking in vivo.Scientific reports · 2024Article
- Chirp excitation for natural frequency optical coherence elastography.Biomedical optics express · 2024Article
- Asynchronous, semi-reverberant elastography.Optica · 2024Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Corneal stiffness plays a critical role in shaping the cornea with respect to intraocular pressure and physical interventions. However, it remains difficult to measure the mechanical properties noninvasively. Here, we report the first measurement of shear modulus in human corneas in vivo using optical coherence elastography (OCE) based on surface elastic waves. In a pilot study of 12 healthy subjects aged between 25 and 67, the Rayleigh-wave speed was 7.86 ± 0.75 m/s, corresponding to a shear modulus of 72 ± 14 kPa. Our data reveal two unexpected trends: no correlation was found between the wave speed and IOP between 13-18 mmHg, and shear modulus decreases with age (- 0.32 ± 0.17 m/s per decade). We propose that shear stiffness is governed by the interfibrillar matrix, whereas tensile strength is dominated by collagen fibrils. Rayleigh-wave OCE may prove useful for clinical diagnosis, refractive surgeries, and treatment monitoring.
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