ArticleScientific reports2020
A site-specific map of the human plasma glycome and its age and gender-associated alterations.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer.Nature communications · 2025Article
- Plasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalities.Journal of advanced research · 2024Article
- Age-Related Changes in SerumBiomolecules · 2023Article
- Immunomodulatory role of glycoRNAs in the brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- Measuring biological age using omics data.Nature reviews. Genetics · 2022Review
- Serum N-glycomic profiling may provide potential signatures for surveillance of COVID-19.Glycobiology · 2022Article
- Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation.Biotechnology and bioengineering · 2022Review
- Diet affects glycosylation of serum proteins in women at risk for cardiometabolic disease.European journal of nutrition · 2021Article
- Glycomic profiling and the mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Glycoprotein Pathways Altered in Frontotemporal Dementia With Autoimmune Disease.Frontiers in immunology · 2021Article
- Glycosylation and Aging.Advances in experimental medicine and biology · 2021Article
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Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
Abstract
Alterations in the human glycome have been associated with cancer and autoimmunity. Thus, constructing a site-specific map of the human glycome for biomarker research and discovery has been a highly sought-after objective. However, due to analytical barriers, comprehensive site-specific glycoprofiling is difficult to perform. To develop a platform to detect easily quantifiable, site-specific, disease-associated glycan alterations for clinical applications, we have adapted the multiple reaction monitoring mass spectrometry method for use in glycan biomarker research. The adaptations allow for highly precise site-specific glycan monitoring with minimum sample prep. Using this technique, we successfully mapped out the relative abundances of the most common 159 glycopeptides in the plasma of 97 healthy volunteers. This plasma glycome map revealed 796 significant (FDR < 0.05) site-specific inter-protein and intra-protein glycan associations, of which the vast majority were previously unknown. Since age and gender are relevant covariants in biomarker research, these variables were also characterized. 13 glycopeptides were found to be associated with gender and 41 to be associated with age. Using just five age-associated glycopeptides, a highly accurate age prediction model was constructed and validated (r
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Registered trials
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