Evidence map›Paper›PMID 33060632›Full record

Trial reportScientific reports2020

Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD.

Alen Faiz, Kai Imkamp, Erica van der Wiel, Ilse M Boudewijn, Gerard H Koppelman, Corry-Anke Brandsma, Huib A M Kerstjens, Wim Timens, Sebastiaan Vroegop, Henk R Pasma and 10 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 2 countries.

Alen FaizDepartment of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
Kai ImkampDepartment of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands. k.imkamp@umcg.nl.
Erica van der WielDepartment of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
Ilse M BoudewijnDepartment of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
Gerard H KoppelmanGRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-8567-3252
Corry-Anke BrandsmaGRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-8911-3658
Huib A M KerstjensDepartment of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.ORCID 0000-0001-7705-7927
Wim TimensGRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-4146-6363
Sebastiaan VroegopDepartment of Pulmonary Diseases, Martini Hospital Groningen, Groningen, The Netherlands.
Henk R PasmaDepartment of Pulmonary Diseases, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
Wim G BoersmaDepartment of Pulmonary Diseases, Medical Center Alkmaar, Alkmaar, The Netherlands.
Pascal WieldersDepartment of Pulmonary Diseases, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.ORCID 0000-0003-3719-5967
Frank van den ElshoutDepartment of Pulmonary Diseases, Rijnstate Hospital, Arnhem, The Netherlands.
Khaled MansourDepartment of Pulmonary Diseases, Orbis Concern, Sittard, The Netherlands.
Katrina SteilingDivision of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Avrum SpiraDivision of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Marc E LenburgDivision of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Irene H HeijinkGRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Dirkje S PostmaDepartment of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
Maarten van den BergeDepartment of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
University Medical Center Groningen · NLBoston University · USMartini Ziekenhuis · NLMedisch Centrum Alkmaar · NLMedisch Centrum Leeuwarden · NLRadboud University Nijmegen · NLRijnstate Hospital · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperinflation contributes to dyspnea intensity in COPD. Little is known about the molecular mechanisms underlying hyperinflation and how inhaled corticosteroids (ICS) affect this important aspect of COPD pathophysiology. To investigate the effect of ICS/long-acting β

Indexed as

Gene Expression ProfilingAdministration, InhalationAdrenergic beta-2 Receptor AgonistsAgedBronchodilator AgentsBudesonideCase-Control StudiesDose-Response Relationship, DrugFemaleFormoterol FumarateHumansLungMaleMiddle AgedNasal CavityPlacebosAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsBudesonideFormoterol FumaratePlacebos

Identifiers

PMID33060632
PMCPMC7562702
OpenAlexW3093083947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.