Evidence map›Paper›PMID 33060603›Full record

ReviewNature communications2020

Multiplying the efficiency and impact of biofortification through metabolic engineering.

Dominique Van Der Straeten, Navreet K Bhullar, Hans De Steur, Wilhelm Gruissem, Donald MacKenzie, Wolfgang Pfeiffer, Matin Qaim, Inez Slamet-Loedin, Simon Strobbe, Joe Tohme and 5 more

Abstract readReview
In one paragraph

Review in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Climate Change Threatens Micronutrient Density of European Winter Wheat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Article
  7. Selenium biofortification: integrating one health and sustainability.Journal of the science of food and agriculture · 2026
    Review
  8. From paddy soil to dining table: biological biofortification of rice with zinc.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Review
  9. Review
  10. Biofortification of kale with vitamin BCurrent research in food science · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Crops and rising atmospheric COPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Horticulture research · 2025
    Article
  19. Review
  20. Animal-sourced foods improve child nutrition in Africa.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dominique Van Der StraetenLaboratory of Functional Plant Biology, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000, Ghent, Belgium. Dominique.VanDerStraeten@UGent.be.ORCID 0000-0002-7755-1420
Navreet K BhullarDepartment of Biology, Institute of Molecular Plant Biology, ETH Zurich, Universitaetstrasse 2, 8092, Zurich, Switzerland.ORCID 0000-0003-1657-0422
Hans De SteurDepartment of Agricultural Economics, Ghent University, Coupure Links 653, B-9000, Ghent, Belgium.ORCID 0000-0003-1340-0882
Wilhelm GruissemDepartment of Biology, Institute of Molecular Plant Biology, ETH Zurich, Universitaetstrasse 2, 8092, Zurich, Switzerland.
Donald MacKenzieDonald Danforth Plant Science Center, St. Louis, MO, 63132, USA.ORCID 0000-0002-9979-8299
Wolfgang PfeifferHarvestPlus c/o IFPRI, Washington, DC, USA.
Matin QaimDepartment of Agricultural Economics and Rural Development, University of Goettingen, Platz der Goettinger Sieben 5, 37073, Goettingen, Germany.ORCID 0000-0003-4143-0763
Inez Slamet-LoedinInternational Rice Research Institute, Manila, The Philippines.
Simon StrobbeLaboratory of Functional Plant Biology, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000, Ghent, Belgium.ORCID 0000-0003-0583-9406
Joe TohmeInternational Center for Tropical Agriculture, CIAT, Cali, Colombia.
Kurniawan Rudi TrijatmikoInternational Rice Research Institute, Manila, The Philippines.ORCID 0000-0002-6440-9150
Hervé VanderschurenTropical Crop Improvement Lab, Department of Biosystems, KU Leuven, Heverlee, Belgium.ORCID 0000-0003-2102-9737
Marc Van MontaguInternational Plant Biotechnology Outreach, B-9052, Zwijnaarde, Belgium.ORCID 0000-0003-4711-5131
Chunyi ZhangBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID 0000-0001-5685-6412
Howarth BouisInternational Food Policy Research Institute, Washington, DC, USA. H.Bouis@CGIAR.org.ORCID 0000-0001-5432-9192

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ending all forms of hunger by 2030, as set forward in the UN-Sustainable Development Goal 2 (UN-SDG2), is a daunting but essential task, given the limited timeline ahead and the negative global health and socio-economic impact of hunger. Malnutrition or hidden hunger due to micronutrient deficiencies affects about one third of the world population and severely jeopardizes economic development. Staple crop biofortification through gene stacking, using a rational combination of conventional breeding and metabolic engineering strategies, should enable a leap forward within the coming decade. A number of specific actions and policy interventions are proposed to reach this goal.

Indexed as

BiofortificationBreedingCrops, AgriculturalDeveloping CountriesFood, FortifiedFood SupplyGlobal HealthHumansMalnutritionMetabolic EngineeringMicronutrientsMineralsOryzaPlantsPlants, Genetically ModifiedPolicy MakingMicronutrientsMineralsProvitaminsVitamins

Identifiers

PMID33060603
PMCPMC7567076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.