Evidence map›Paper›PMID 33060596›Full record

ArticleNature communications2020

Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles.

Ming Yuan Li, Trupti Shivaprasad Naik, Lewis Yu Lam Siu, Oreste Acuto, Eric Spooner, Peigang Wang, Xiaohan Yang, Yongping Lin, Roberto Bruzzone, Joseph Ashour and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
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  8. Article
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  11. Article
  12. Bioprofiling and vaccine development for Zika virus.Science China. Life sciences · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Nonlytic Egress and Transmission in the Virus World.Annual review of biochemistry · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 6 countries.

Ming Yuan LiHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR.
Trupti Shivaprasad NaikHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR.
Lewis Yu Lam SiuHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR.
Oreste AcutoSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
Eric SpoonerWhitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA, 02142, USA.
Peigang WangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, 100069, Beijing, China.ORCID 0000-0001-6045-2007
Xiaohan YangMedical Genetic Centre, Guangdong Women and Children Hospital, 511400, Guangdong, China.
Yongping LinDepartment of Laboratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, 510120, Guangdong, China.
Roberto BruzzoneHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR.ORCID 0000-0003-4373-1447
Joseph AshourDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matthew J EvansDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sumana SanyalHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR. sumana.sanyal@path.ox.ac.uk.ORCID 0000-0002-6230-5366
HKU-Pasteur Research Pole · HKUniversity of Oxford · GBBoehringer Ingelheim (Egypt) · EGCapital Medical University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNGuangdong Province Women and Children Hospital · CNIcahn School of Medicine at Mount Sinai · USWhitehead Institute for Biomedical Research · US

Funding

Wellcome Trust 200844/Z/16/Z
6 · The paper itself

Abstract

Among the various host cellular processes that are hijacked by flaviviruses, few mechanisms have been described with regard to viral egress. Here we investigate how flaviviruses exploit Src family kinases (SFKs) for exit from infected cells. We identify Lyn as a critical component for secretion of Dengue and Zika infectious particles and their corresponding virus like particles (VLPs). Pharmacological inhibition or genetic depletion of the SFKs, Lyn in particular, block virus secretion. Lyn

Indexed as

AnimalsAutophagosomesAutophagyAutophagy-Related Protein-1 HomologCell LineChlorocebus aethiopsDengueDengue VirusFlavivirusHost Microbial InteractionsHumansIntracellular Signaling Peptides and Proteinsrab GTP-Binding ProteinsSecretory PathwaySNARE Proteinssrc-Family KinasesAutophagy-Related Protein-1 HomologIntracellular Signaling Peptides and Proteinslyn protein-tyrosine kinaserab GTP-Binding ProteinsSNARE Proteinssrc-Family KinasesULK1 protein, human

Identifiers

PMID33060596
PMCPMC7564011
OpenAlexW3093343220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.