SynthesisNature communications2020
Synthesis and systematic review of reported neonatal SARS-CoV-2 infections.
Synthesis in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
165 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review.BMC medicine · 2024Pooled it
- Pregnancy and COVID-19: high or low risk of vertical transmission.Clinical and experimental medicine · 2023Pooled it
- Mother-to-child transmission of SARS-CoV-2 infection in high-income countries: a systematic review and meta-analysis of prospective observational studies.Scientific reports · 2023Pooled it
- Effects of intrauterine exposure to SARS-CoV-2 on infants' development: a rapid review and meta-analysis.European journal of pediatrics · 2023Pooled it
- COVID-19 in Neonates with Positive RT-PCR Test. Systematic Review.Archives of medical research · 2022Pooled it
- SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis.BMJ (Clinical research ed.) · 2022Pooled it
- Pooled it
- COVID-19: Critical appraisal of the evidence.Anales de pediatria · 2021Pooled it
- COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes.PloS one · 2021Pooled it
- Clinical Characteristics and Neonatal Outcomes of Pregnant Patients With COVID-19: A Systematic Review.Frontiers in medicine · 2020Pooled it
- Multisystem COVID-19 in an Ex-22 Week Extremely Preterm Infant With Severe Bronchopulmonary Dysplasia - A Case Report.Journal of paediatrics and child health · 2026Article
- Attitudes to mandatory COVID-19 vaccination in early life: findings from the multi-country cross-sectional CANDOUR study.Health promotion international · 2026Article
- Intra-Omicron Reinfection with JN.1.16 and NB.1.8.1 in a Preterm Infant: First NB.1.8.1 Detection in Tunisia-A Case Report.Microorganisms · 2026Article
- Article
- The association between early pregnancy infection with SARS-CoV-2 and fetal birth defects: a prospective study.Scientific reports · 2026Article
- SARS-CoV-2 infects human primary cytotrophoblasts mainly through a non-canonical entry route.Molecular human reproduction · 2026Article
- Maternal Coronavirus Disease 2019 Test Positivity and Neonatal Intensive Care Unit Outcomes for Infants Born Extremely Preterm.The Journal of pediatrics · 2026Article
- Neonatal multisystem inflammatory syndrome (MIS-N) associated with prenatal maternal SARS-CoV-2: a single-center experience.BMC pediatrics · 2025Article
- ESICM-ESPNIC international expert consensus on quantitative lung ultrasound in intensive care.Intensive care medicine · 2025Article
105 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. We report that 70% and 30% of infections are due to environmental and vertical transmission, respectively. Our analysis shows that 55% of infected neonates developed COVID-19; the most common symptoms were fever (44%), gastrointestinal (36%), respiratory (52%) and neurological manifestations (18%), and lung imaging was abnormal in 64% of cases. A lack of mother-neonate separation from birth is associated with late SARS-CoV-2 infection (OR 4.94 (95% CI: 1.98-13.08), p = 0.0002; adjusted OR 6.6 (95% CI: 2.6-16), p < 0.0001), while breastfeeding is not (OR 0.35 (95% CI: 0.09-1.18), p = 0.10; adjusted OR 2.2 (95% CI: 0.7-6.5), p = 0.148). Our findings add to the literature on neonatal SARS-CoV-2 infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.