Evidence map›Paper›PMID 33060502›Full record

SynthesisCritical care medicine2020

Prediction Models for Physical, Cognitive, and Mental Health Impairments After Critical Illness: A Systematic Review and Critical Appraisal.

Kimberley J Haines, Elizabeth Hibbert, Joanne McPeake, Brian J Anderson, Oscar Joseph Bienvenu, Adair Andrews, Nathan E Brummel, Lauren E Ferrante, Ramona O Hopkins, Catherine L Hough and 11 more

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 4 countries.

Kimberley J HainesDepartment of Physiotherapy, Western Health, Sunshine Hospital, Melbourne, VIC, Australia.
Elizabeth HibbertDepartment of Physiotherapy, Western Health, Sunshine Hospital, Melbourne, VIC, Australia.
Joanne McPeakeGlasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Scotland, United Kingdom.
Brian J AndersonDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Oscar Joseph BienvenuDivision of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA.
Adair AndrewsSociety of Critical Care Medicine, Chicago, IL.
Nathan E BrummelDivision of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Lauren E FerranteSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT.
Ramona O HopkinsDepartment of Psychology and Neuroscience Center, Brigham Young University, Provo, UT.
Catherine L HoughDivision of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR.
James JacksonDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.
Mark E MikkelsenDivision of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky, Lexington, KY.
Nina LeggettDepartment of Physiotherapy, Western Health, Sunshine Hospital, Melbourne, VIC, Australia.
Ashley Montgomery-YatesDivision of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA.
Dale M NeedhamPulmonary and Critical Care Medicine, and Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD.
Carla M SevinVanderbilt University School of Medicine, Nashville, TN.
Becky SkidmoreIndependent Information Specialist, Ottawa, ON, Canada.
Mary StillEmory University Hospital (Emory Healthcare), Atlanta, GA.
Maarten van SmedenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Gary S CollinsCentre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Michael O HarhayDepartment of Biostatistics, Epidemiology and Informatics, and Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
The Ohio State University Wexner Medical Center · USBrigham Young University · USNuffield Orthopaedic Centre · GBOregon Health & Science University · USSociety of Critical Care Medicine · USUniversity of Glasgow · GBUniversity of Kentucky · USUniversity of Melbourne · AUUniversity of Pennsylvania · USUtrecht University · NLVanderbilt University · USVanderbilt University Medical Center · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trial of Combined Cycle Ergometry and Amino Acids in the ICUR01HL132887 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HEYLAND, DAREN KEITH, NEEDHAM, DALE MURRAY · 2017 to 2021
$3.5M
The PREDICT Study (PRE-ICU Determinants of Post-ICU FunCTional Outcomes among Older Adults)K76AG057023 · NIA · YALE UNIVERSITY · PI FERRANTE, LAUREN · 2017 to 2022
$1.3M
Neurocognitive Impairment in Acute Respiratory Failure and Shock: Understanding the Role of Neuronal ExcitotoxicityK23HL140482 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ANDERSON, BRIAN J. · 2018 to 2022
$959k
Improving the measurement and analysis of long-term, patient-centered outcomes following acute respiratory failureR00HL141678 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HARHAY, MICHAEL OSCAR · 2020 to 2022
$747k
Improving the measurement and analysis of long-term, patient-centered outcomes following acute respiratory failureK99HL141678 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HARHAY, MICHAEL OSCAR · 2018 to 2019
$214k
Cancer Research UK 27294Cancer Research UK C49297/A27294NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K23 HL140482NHLBI NIH HHS K99 HL141678NHLBI NIH HHS R00 HL141678NHLBI NIH HHS R01 HL132887NIA NIH HHS K76 AG057023
6 · The paper itself

Abstract

objectivesImproved ability to predict impairments after critical illness could guide clinical decision-making, inform trial enrollment, and facilitate comprehensive patient recovery. A systematic review of the literature was conducted to investigate whether physical, cognitive, and mental health impairments could be predicted in adult survivors of critical illness. DATA SOURCES: A systematic search of PubMed and the Cochrane Library (Prospective Register of Systematic Reviews ID: CRD42018117255) was undertaken on December 8, 2018, and the final searches updated on January 20, 2019. STUDY SELECTION: Four independent reviewers assessed titles and abstracts against study eligibility criteria. Studies were eligible if a prediction model was developed, validated, or updated for impairments after critical illness in adult patients. Discrepancies were resolved by consensus or an independent adjudicator. DATA EXTRACTION: Data on study characteristics, timing of outcome measurement, candidate predictors, and analytic strategies used were extracted. Risk of bias was assessed using the Prediction model Risk Of Bias Assessment Tool. DATA SYNTHESIS: Of 8,549 screened studies, three studies met inclusion. All three studies focused on the development of a prediction model to predict (1) a mental health composite outcome at 3 months post discharge, (2) return-to-pre-ICU functioning and residence at 6 months post discharge, and (3) physical function 2 months post discharge. Only one model had been externally validated. All studies had a high risk of bias, primarily due to the sample size, and statistical methods used to develop and select the predictors for the prediction published model.

conclusionsWe only found three studies that developed a prediction model of any post-ICU impairment. There are several opportunities for improvement for future prediction model development, including the use of standardized outcomes and time horizons, and improved study design and statistical methodology.

Indexed as

Activities of Daily LivingCognitive DysfunctionCritical IllnessHumansIntensive Care UnitsMental DisordersModels, StatisticalSurvivorsTreatment Outcome

Identifiers

PMID33060502
PMCPMC7673641
OpenAlexW3093473478

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.