ArticleJournal of acquired immune deficiency syndromes (1999)2020
Brief Report: Chronic Placental Inflammation Among Women Living With HIV in Uganda.
Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Cytomegalovirus and HIV Co-Infections During Pregnancy and Early Childhood.Current HIV/AIDS reports · 2026Review
- HIV and Syphilis Coinfection in Pregnancy and Adverse Birth Outcomes in Uganda.The Journal of infectious diseases · 2026Article
- Maternal inflammation disrupts transplacental antibody transfer in pregnant individuals with and without HIV.Frontiers in immunology · 2026Article
- Defining Appropriate Comparator Populations for Placental Pathology for Pregnant People With HIV.International journal of surgical pathology · 2025Article
- HIV-related Differences in Placental Immunology: Data From the PRACHITi Cohort in Pune, India.Open forum infectious diseases · 2025Article
- Effects of Maternal HIV Infection and Alcohol Use in Pregnancy on Birth Outcomes in Uganda.AIDS and behavior · 2024Article
- Maternal anemia is associated with adverse maternal and neonatal outcomes in Mbarara, Uganda.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2023Article
- Article
- Altered Maternal Antibody Profiles in Women With Human Immunodeficiency Virus Drive Changes in Transplacental Antibody Transfer.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Building Perinatal Pathology Research Capacity in Sub-Saharan Africa.Frontiers in medicine · 2022Article
- Placental Decidual Arteriopathy and Vascular Endothelial Growth Factor A Expression Among Women With or Without Human Immunodeficiency Virus.The Journal of infectious diseases · 2021Article
- Unique Severe COVID-19 Placental Signature Independent of Severity of Clinical Maternal Symptoms.Viruses · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHIV-exposed, uninfected (HEU) children have poorer early-life outcomes than HIV-unexposed children. The determinants of adverse health outcomes among HEU children are poorly understood but may result from chronic placental inflammation (CPI). SETTING AND
methodsWe enrolled 176 pregnant women living with HIV (WLWH) taking antiretroviral therapy in southwestern Uganda and 176 HIV-uninfected women to compare CPI prevalence by maternal HIV serostatus. Placentas were evaluated histologically by an expert pathologist for presence of CPI, defined as chronic chorioamnionitis, plasma cell deciduitis, villitis of unknown etiology, or chronic histiocytic intervillositis. Placentas with CPI were additionally immunostained with CD3 (T cell), CD20 (B cell), and CD68 (macrophage) markers to characterize inflammatory cell profiles.
resultsWLWH and HIV-uninfected women had similar age, parity, and gestational age. Among WLWH, the mean CD4 count was 480 cells/µL, and 74% had an undetectable HIV viral load. We detected CPI in 16 (9%) placentas from WLWH and 24 (14%) from HIV-uninfected women (P = 0.18). Among WLWH, CPI was not associated with the CD4 count or HIV viral load. Villitis of unknown etiology was twice as common among HIV-uninfected women than WLWH (10 vs. 5%, P = 0.04). Among placentas with CPI, more villous inflammatory cells stained for CD3 or CD68 among HIV-uninfected women than WLWH (79% vs. 46%, P = 0.07).
conclusionsCPI prevalence did not differ by HIV serostatus. T-cell (CD3) and macrophage (CD68) markers were more prevalent in placental inflammatory cells from HIV-uninfected women. Our results do not support CPI as a leading mechanism for poor outcomes among HEU children in the antiretroviral therapy era.
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