Evidence map›Paper›PMID 33060197›Full record

ArticleScience (New York, N.Y.)2020

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

David E Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V Rezelj, Svenja Ulferts, Hannes Braberg, Alexander S Jureka, Kirsten Obernier, Jeffrey Z Guo, Jyoti Batra and 190 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 473 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
473citing papers in PubMed, 1 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

473 citing papers in PubMed, 1 synthesis or guideline pooled it, 801 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Structural Features of a Tiny Viral Protein, ORF7b of SARS-CoV-2.International journal of molecular sciences · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Dynamic disorder is crucial for mitochondrial protein import.Protein science : a publication of the Protein Society · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Fold-Switching Proteins.Annual review of biophysics · 2026
    Review
  19. Article
  20. Article

413 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

200 authors at 20 institutions in 5 countries.

David E Gordon *Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-7954-0306
Joseph Hiatt *Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-8015-9614
Mehdi Bouhaddou *Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-9526-1427
Veronica V Rezelj *Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France.ORCID 0000-0003-1571-8325
Svenja Ulferts *Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-6605-8163
Hannes Braberg *Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-7070-2257
Alexander S Jureka *Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0001-6839-1835
Kirsten Obernier *Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-4025-1299
Jeffrey Z Guo *Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0003-2857-9870
Jyoti Batra *Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-2335-0607
Robyn M Kaake *Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-8341-3067
Andrew R Weckstein *Aetion, Inc., New York, NY 10001, USA.ORCID 0000-0002-6227-6796
Tristan W Owens *QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-7423-4879
Meghna Gupta *QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-7432-3211
Sergei Pourmal *QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-7537-6016
Erron W Titus *QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-6868-9121
Merve Cakir *Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0003-1803-5693
Margaret SoucherayQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-0370-6653
Michael McGregorQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-5281-5736
Zeynep CakirQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.
Gwendolyn JangQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-7806-9874
Matthew J O'MearaDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3128-5331
Tia A TumminoQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-9155-820X
Ziyang ZhangQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0003-0541-7211
Helene FoussardQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-5063-113X
Ajda RojcQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-6183-7109
Yuan ZhouQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-1393-5476
Dmitry KuchenovQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.
Ruth HüttenhainQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-0896-5910
Jiewei XuQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-8647-4172
Manon EckhardtQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-8143-6129
Danielle L SwaneyQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-6119-6084
Jacqueline M FabiusQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.
Manisha UmmadiQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.
Beril TutuncuogluQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-5458-2988
Ujjwal RathoreQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-0329-7431
Maya ModakQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-0670-6683
Paige HaasQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-8303-457X
Kelsey M HaasQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-1463-6726
Zun Zar Chi NaingQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-6320-5084
Ernst H PulidoQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-3616-9743
Ying ShiQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.
Inigo Barrio-HernandezEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0002-5686-0451
Danish MemonEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
Eirini PetsalakiEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0002-7514-4362
Alistair DunhamEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0001-9076-3025
Miguel Correa MarreroEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0002-3840-3273
David BurkeEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0001-8830-3951
Cassandra KohViral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France.ORCID 0000-0003-2466-6731
Thomas ValletViral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France.ORCID 0000-0001-7775-7448
Jesus A SilvasCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-1200-803X
Caleigh M AzumayaQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-3484-9921
Christian BillesbølleQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-8084-1552
Axel F BrilotQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-8548-4224
Melody G CampbellQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-1909-5751
Amy DialloQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-9843-2255
Miles Sasha DickinsonQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-8016-1570
Devan DiwanjiQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-4285-435X
Nadia HerreraQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.
Nick HoppeQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-0265-5337
Huong T KratochvilQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-8039-6823
Yanxin LiuQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-2253-3698
Gregory E MerzQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-0842-4935
Michelle MoritzQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-3811-5623
Henry C NguyenQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-6142-8807
Carlos NowotnyQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-1260-0279
Cristina PuchadesQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-3240-4176
Alexandrea N RizoQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-4813-6348
Ursula Schulze-GahmenQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-3919-4474
Amber M SmithQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-0669-1589
Ming SunQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-4413-2502
Iris D YoungQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-4713-9504
Jianhua ZhaoQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-4997-766X
Daniel AsarnowQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.
Justin BielQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-0935-8362
Alisa BowenQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-8518-6697
Julian R BraxtonQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-1170-5140
Jen ChenQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.
Cynthia M ChioQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-8381-1957
Un Seng ChioQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-5295-2690
Ishan DeshpandeQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-8276-9635
Loan DoanQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.
Bryan FaustQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-4126-6409
Sebastian FloresQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-6812-3988
Mingliang JinQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-4961-7143
Kate KimQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-8821-6663
Victor L LamQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.
Fei LiQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-0720-3129
Junrui LiQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-7426-9596
Yen-Li LiQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-7095-3507
Yang LiQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-0216-0350
Xi LiuQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-9002-3553
Megan LoQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-6387-8182
Kyle E LopezQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.
Arthur A MeloQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-9345-1462
Frank R MossQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-6149-6447
Phuong NguyenQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.
Joana PaulinoQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-8846-822X
Komal Ishwar PawarQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-1968-9851
Jessica K PetersQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-3541-7431
Thomas H PospiechQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-3630-3794
Maliheh SafariQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-9511-6481
Smriti SangwanQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-3772-7142
Kaitlin SchaeferQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.
Paul V ThomasQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-6772-3997
Aye C ThwinQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-1423-8189
Raphael TrenkerQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-1748-0517
Eric TseQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-2082-9006
Tsz Kin Martin TsuiQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-5741-1941
Feng WangQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-1233-2745
Natalie WhitisQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-9073-2093
Zanlin YuQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-8381-8788
Kaihua ZhangQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-3734-3624
Yang ZhangQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-7497-3206
Fengbo ZhouQBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.
Daniel SaltzbergQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-8641-6194
QCRG Structural Biology Consortium
Anthony J HodderDepartment of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK.ORCID 0000-0001-5906-0794
Amber S Shun-ShionDepartment of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK.ORCID 0000-0001-6439-7893
Daniel M WilliamsDepartment of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK.ORCID 0000-0001-8483-021X
Kris M WhiteDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-0889-0506
Romel RosalesDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-5326-4753
Thomas KehrerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-6433-0098
Lisa MiorinDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-0989-3178
Elena MorenoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-2301-4558
Arvind H PatelMRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK.ORCID 0000-0003-4600-2047
Suzannah RihnMRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK.ORCID 0000-0001-9495-4056
Mir M KhalidJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-1862-6795
Albert Vallejo-GraciaJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0003-4815-5039
Parinaz FozouniJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-6710-1506
Camille R SimoneauJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0001-9222-8130
Theodore L RothMedical Scientist Training Program, University of California, San Francisco, CA 94143, USA.
David WuMedical Scientist Training Program, University of California, San Francisco, CA 94143, USA.
Mohd Anisul KarimWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
Maya GhoussainiWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.ORCID 0000-0002-2415-2143
Ian DunhamEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0003-2525-5598
Francesco BerardiDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'ALDO MORO', Via Orabona, 4 70125, Bari, Italy.
Sebastian WeigangInstitute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-8415-6920
Maxime ChazalDépartement de Virologie, CNRS UMR 3569, Institut Pasteur, Paris 75015, France.ORCID 0000-0002-3144-5032
Jisoo ParkDepartment of Medicine, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-3077-1979
James LogueDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-7410-9741
Marisa McGrathDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-7451-4958
Stuart WestonDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0001-9840-2953
Robert HauptDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0001-8300-7184
C James HastieMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0001-7164-4098
Matthew ElliottMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0002-1223-3253
Fiona BrownMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0002-5677-2945
Kerry A BurnessMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0001-8086-1078
Elaine ReidMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0001-8095-7387
Mark DorwardMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0001-5765-0926
Clare JohnsonMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Stuart G WilkinsonMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0003-3839-1556
Anna GeyerMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0001-7539-7979
Daniel M GieselMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0001-8971-2511
Carla BaillieMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Samantha RaggettMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0002-3904-9050
Hannah LeechMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0003-2474-1471
Rachel TothMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Nicola GoodmanMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0003-1339-9869
Kathleen C KeoughJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-7481-0511
Abigail L LindJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-9579-4178
Zoonomia Consortium
Reyna J KleshHealthVerity, Philadelphia, PA 19103, USA.ORCID 0000-0003-2095-3661
Kafi R HemphillDepartment of Neurology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-9468-7082
Jared Carlson-StevermerSynthego Corporation, Redwood City, CA 94063, USA.ORCID 0000-0001-7824-0950
Jennifer OkiSynthego Corporation, Redwood City, CA 94063, USA.ORCID 0000-0003-0147-0269
Kevin HoldenSynthego Corporation, Redwood City, CA 94063, USA.ORCID 0000-0002-3091-4124
Travis MauresSynthego Corporation, Redwood City, CA 94063, USA.
Katherine S PollardJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-9870-6196
Andrej SaliQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0003-0435-6197
David A AgardQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0003-3512-695X
Yifan ChengQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-9535-0369
James S FraserQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-5080-2859
Adam FrostQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0003-2231-2577
Natalia JuraQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-5129-641X
Tanja KortemmeQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-8494-680X
Aashish ManglikQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-7173-3741
Daniel R SouthworthQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.
Robert M StroudQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0003-2083-5665
Dario R AlessiMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0002-2140-9185
Paul DaviesMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0001-8022-2719
Matthew B FriemanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-0107-0775
Trey IdekerDepartment of Medicine, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-1708-8454
Carmen AbateDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'ALDO MORO', Via Orabona, 4 70125, Bari, Italy.
Nolwenn JouvenetInstitute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0001-6103-6048
Georg KochsInstitute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0003-0187-559X
Brian ShoichetQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0002-6098-7367
Melanie OttJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-5697-1274
Massimo PalmariniMRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK.ORCID 0000-0001-7007-4070
Kevan M ShokatQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.ORCID 0000-0001-8590-7741
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.ORCID 0000-0002-6551-1827
Jeremy A RassenAetion, Inc., New York, NY 10001, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.ORCID 0000-0003-4369-7381
Robert GrosseInstitute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.
Oren S RosenbergQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.ORCID 0000-0002-5736-4388
Kliment A VerbaQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.ORCID 0000-0002-2238-8590
Christopher F BaslerCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.ORCID 0000-0003-4195-425X
Marco VignuzziViral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.ORCID 0000-0002-4400-771X
Andrew A PedenDepartment of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.ORCID 0000-0003-0144-7712
Pedro BeltraoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.ORCID 0000-0002-2724-7703
Nevan J KroganQuantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.ORCID 0000-0003-4902-337X
University of California System · USGladstone Institutes · USUniversity of California, San Francisco · USUniversity of Dundee · GBEuropean Bioinformatics Institute · GBCentre National de la Recherche Scientifique · FRHoward Hughes Medical Institute · USIcahn School of Medicine at Mount Sinai · USSynthego (United States) · USUniversity of Freiburg · DEUniversity of Maryland, Baltimore · USUniversity of Sheffield · GBGeorgia State University · USMRC University of Glasgow Centre for Virus Research · GBAetion (United States) · USUniversity of Bari Aldo Moro · ITUniversity of California San Diego · USWellcome Sanger Institute · GBPhiladelphia Department of Public Health · USTisch Hospital · US

Funding

The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI PORTNOY, DANIEL A · 2004 to 2025
$45.5M
Virology BSL4 CoreP01AI120943 · NIAID · WASHINGTON UNIVERSITY · PI Gaya K. Amarasinghe · 2016 to 2026
$30.2M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
SARS-CoV adaptations through a Systems Biology Lens (SYBIL)U19AI135972 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Adolfo Garcia-Sastre · 2018 to 2026
$27.2M
RESEARCH PROJECT 2U19AI135990 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Melanie Maria Ott · 2018 to 2026
$21.4M
X-ray Screening and Rapid Structure DeterminationP50AI150476 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EMERMAN, MICHAEL · 2019 to 2021
$14.4M
STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1M
Development and Testing of New Computational Methods for Ligand Discovery and MechanismR35GM122481 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian K Shoichet · 2017 to 2026
$8.5M
STRUCTURE/FUNCTION OF PROTEINS AT MOLECULAR LEVELR01GM024485 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 1985 to 2024
$7.5M
Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
Structural Basis of Vesicular Neurotransmitter TransportR01NS089713 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARDS, ROBERT H, STROUD, ROBERT M · 2015 to 2023
$5.8M
Novel VP30-host Interactions that Negatively Regulate Ebola Virus InfectionR01AI143292 · NIAID · WASHINGTON UNIVERSITY · PI AMARASINGHE, GAYA K., BASLER, CHRISTOPHER F · 2019 to 2023
$4.0M
Biotechnology and Biological Sciences Research Council BB/J014443/1Howard Hughes Medical InstituteMedical Research Council MC_PC_19026Medical Research Council MC_UU_00018/1Medical Research Council MC_UU_12014/2Medical Research Council MC_UU_12016/2Medical Research Council MR/V03541X/1NCI NIH HHS F32 CA239333NCI NIH HHS F32 CA239336NCI NIH HHS R01 CA244550NHGRI NIH HHS R01 HG008742NHGRI NIH HHS R01 HG009979NIAID NIH HHS F30 AI143401NIAID NIH HHS HHSN272201400008CNIAID NIH HHS P01 AI063302NIAID NIH HHS P01 AI120943NIAID NIH HHS P50 AI150476NIAID NIH HHS R01 AI120694NIAID NIH HHS R01 AI122747NIAID NIH HHS R01 AI128214NIAID NIH HHS R01 AI143292NIAID NIH HHS T32 AI060537NIAID NIH HHS U19 AI135972NIAID NIH HHS U19 AI135990NIGMS NIH HHS F32 GM137463NIGMS NIH HHS K99 GM138753NIGMS NIH HHS R01 GM024485NIGMS NIH HHS R35 GM118099NIGMS NIH HHS R35 GM122481NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM008284NINDS NIH HHS R01 NS089713Wellcome Trust 201366/Z/16/Z
6 · The paper itself

Abstract

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study.

Indexed as

Host Microbial InteractionsProtein Interaction MapsConserved SequenceCoronavirus Nucleocapsid ProteinsCOVID-19Cryoelectron MicroscopyHumansMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsPhosphoproteinsProtein ConformationSARS-CoV-2Severe Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusCoronavirus Nucleocapsid ProteinsMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex Proteinsnucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsTOMM70 protein, human

Identifiers

PMID33060197
PMCPMC7808408
OpenAlexW3093213262

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