Evidence map›Paper›PMID 33060184›Full record

ArticleeNeuro

Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Rescue Memory Defects in

Shin-Hann Lee, Sarah M Gomes, Judy Ghalayini, Konstantin G Iliadi, Gabrielle L Boulianne

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  4. Improvement effects of cyclic peptides fromFood science and biotechnology · 2024
    Article
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  13. Article
  14. Observational
  15. Review
  16. The Angiotensin-Converting Enzyme Inhibitor Lisinopril Mitigates Memory and Motor Deficits in aPathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shin-Hann LeeProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA.ORCID 0000-0002-5808-7642
Sarah M GomesProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA.
Judy GhalayiniProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA.ORCID 0000-0003-2045-8206
Konstantin G IliadiProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA.
Gabrielle L BoulianneProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA gboul@sickkids.ca.
University of Toronto · CAHospital for Sick Children · CA

Funding

CIHR PJT153063
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a degenerative disorder that causes progressive memory and cognitive decline. Recently, studies have reported that inhibitors of the mammalian renin angiotensin system (RAS) result in a significant reduction in the incidence and progression of AD by unknown mechanisms. Here, we used a genetic and pharmacological approach to evaluate the beneficial effects of angiotensin converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) in

Indexed as

Alzheimer DiseaseDrosophila ProteinsAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAnimalsDrosophilaHumansMetalloendopeptidasesRenin-Angiotensin SystemTransgenesAcer protein, DrosophilaAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsDrosophila ProteinsMetalloendopeptidasesAlzheimer’s diseaseamyloidDrosophilamemorypresenilinrenin angiotensin system

Identifiers

PMID33060184
PMCPMC7768280
OpenAlexW3092689247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.