Evidence map›Paper›PMID 33060180›Full record

ArticleeNeuro

Controlling Horizontal Cell-Mediated Lateral Inhibition in Transgenic Zebrafish Retina with Chemogenetic Tools.

Billie Beckwith-Cohen, Lars C Holzhausen, Scott Nawy, Richard H Kramer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Synchronous inhibitory pathways create both efficiency and diversity in the retina.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Billie Beckwith-CohenVision Science Graduate Program, University of California, Berkeley, School of Optometry, Berkeley, CA 94720.ORCID 0000-0003-3147-9205
Lars C HolzhausenDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720.
Scott NawyDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720.ORCID 0000-0003-4679-6756
Richard H KramerVision Science Graduate Program, University of California, Berkeley, School of Optometry, Berkeley, CA 94720 rhkramer@berkeley.edu.ORCID 0000-0002-8755-9389
University of California, Berkeley · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Horizontal cells (HCs) form reciprocal synapses with rod and cone photoreceptors, an arrangement that underlies lateral inhibition in the retina. HCs send negative and positive feedback signals to photoreceptors, but how HCs initiate these signals remains unclear. Unfortunately, because HCs have no unique neurotransmitter receptors, there are no pharmacological treatments for perturbing membrane potential specifically in HCs. Here we use transgenic zebrafish whose HCs express alien receptors, enabling cell-type-specific control by cognate alien agonists. To depolarize HCs, we used the Phe-Met-Arg-Phe-amide (FMRFamide)-gated Na

Indexed as

Retinal Horizontal CellsZebrafishAnimalsMembrane PotentialsRetinaRetinal Cone Photoreceptor Cellsfeedback inhibitionfluorescent proteinhorizontal celllateral inhibitionphotoreceptorretina

Identifiers

PMID33060180
PMCPMC7665903
OpenAlexW3092790207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.