ArticleCancer research2020
An Integrative Gene Expression and Mathematical Flux Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells.
Abstract read
In one paragraph
Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Pharmacological features of mesoionic compounds: antitumoral effects and bioenergetic disruption of sydnones and 1,3,4-thiadiazolium derivatives.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- An enrichment-based approach to interpreting metabolomic data using differential metabolomic profiles within the iDMET framework.BMC bioinformatics · 2026Article
- Unravelling the role of natural herbs for the management of diabetes mellitus.Diabetology & metabolic syndrome · 2025Review
- Systems Biology of the Cancer Cell.Annual review of biomedical engineering · 2025Review
- Emodin and Aloe-Emodin Reduce Cell Growth and Disrupt Metabolic Plasticity in Human Melanoma Cells.Nutrients · 2025Article
- Proteomic and metabolomic insights into oxidative stress response activation in mouse embryos generated byHuman reproduction open · 2025Article
- Current Insights into the Role of UV Radiation-Induced Oxidative Stress in Melanoma Pathogenesis.International journal of molecular sciences · 2024Review
- Glutamine metabolism improves left ventricular function but not macrophage-mediated inflammation following myocardial infarction.American journal of physiology. Cell physiology · 2024Article
- Taurine modulates host cell responses toInfection and immunity · 2024Article
- Review
- Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters.Science advances · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
B Bishal PaudelDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee.
Joshua E LewisThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.ORCID 0000-0002-4168-0407
Keisha N HardemanDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee.
Corey E HayfordQuantitative Systems Biology Center (QSBC), Vanderbilt University, Nashville, Tennessee.ORCID 0000-0002-3006-4852
Charles J RobbinsDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee.
Philip E StaufferQuantitative Systems Biology Center (QSBC), Vanderbilt University, Nashville, Tennessee.ORCID 0000-0003-0329-5839
Simona G CodreanuCenter for Innovative Technology, Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee.
Stacy D SherrodCenter for Innovative Technology, Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee.
John A McLeanCenter for Innovative Technology, Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0001-8918-6419
Melissa L KempThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.ORCID 0000-0003-3781-8802
Vito QuarantaDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee. vito.quaranta@vanderbilt.edu.ORCID 0000-0001-7491-8672
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3MTrainingU54CA113007 · NCI · VANDERBILT UNIVERSITY · PI ESTRADA-RODGERS, LOURDES · 2004 to 2014
$19.2MMULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9MSingle-Cell Biology and Data Analysis Shared Resource (SCB-DA SR)U54CA217450 · NCI · VANDERBILT UNIVERSITY · PI WEAVER, ALISSA M · 2018 to 2022
$8.5MModel-based Prediction of Redox-Modulated Responses to Cancer TreatmentsU01CA215848 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI FURDUI, CRISTINA MARIA, KEMP, MELISSA LAMBETH · 2017 to 2021
$3.6MQuantitative Multiscale Imaging to Optimize Cancer Treatment StrategiesR01CA186193 · NCI · VANDERBILT UNIVERSITY · PI QUARANTA, VITO, RERICHA, ERIN C · 2014 to 2019
$3.1MPhenotype Transitions in Small Cell Lung CancerU01CA215845 · NCI · VANDERBILT UNIVERSITY · PI LOPEZ, CARLOS FEDERICO, QUARANTA, VITO · 2017 to 2021
$2.8MImage Driven Multi-Scale Modeling to Predict Treatment Response in Breast CancerU01CA174706 · NCI · VANDERBILT UNIVERSITY · PI QUARANTA, VITO, YANKEELOV, THOMAS E · 2013 to 2018
$2.5MSystems biology modeling of radiation resistance and chemotherapy-radiation combination therapies in head and neck squamous cell carcinomaF30CA224968 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI LEWIS, JOSHUA ELLIOTT · 2018 to 2020
$135kUncovering the Molecular Basis of Phenotypic Diversification in BRAF-mutant MelanomaF31CA221147 · NCI · VANDERBILT UNIVERSITY · PI HAYFORD, COREY EDUARDO · 2017 to 2019
$134kNCI NIH HHS F30 CA224968NCI NIH HHS F31 CA221147NCI NIH HHS R01 CA186193NCI NIH HHS U01 CA174706NCI NIH HHS U01 CA215845NCI NIH HHS U01 CA215848NCI NIH HHS U54 CA113007NCI NIH HHS U54 CA217450NIDDK NIH HHS T32 DK007563NIGMS NIH HHS T32 GM008169
Abstract
Melanomas harboring
Indexed as
Antineoplastic AgentsAntioxidantsComputational BiologyDose-Response Relationship, DrugDrug Resistance, NeoplasmEnzyme InhibitorsGene Expression Regulation, NeoplasticGlutathioneHumansMelanomaNADPNADPH Oxidase 5Oxidation-ReductionOxidative StressProto-Oncogene Proteins B-rafReactive Oxygen SpeciesAntineoplastic AgentsAntioxidantsBRAF protein, humanEnzyme InhibitorsGlutathioneNADPNADPH Oxidase 5NOX5 protein, humanProto-Oncogene Proteins B-rafReactive Oxygen Species
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.