Evidence map›Paper›PMID 33060132›Full record

ArticleDevelopment (Cambridge, England)2020

Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production.

Miguel Turrero García, José-Manuel Baizabal, Diana N Tran, Rui Peixoto, Wengang Wang, Yajun Xie, Manal A Adam, Lauren A English, Christopher M Reid, Salvador I Brito and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Miguel Turrero GarcíaDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
José-Manuel BaizabalDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Diana N TranDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Rui PeixotoHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Wengang WangHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Yajun XieDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Manal A AdamDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Lauren A EnglishSummer Honors Undergraduate Research Program, Harvard Medical School, Boston, MA 02115, USA.
Christopher M ReidDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Salvador I BritoDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Matthew A BookerDepartment of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Michael Y TolstorukovDepartment of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Corey C HarwellDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA corey_harwell@hms.harvard.edu.ORCID 0000-0002-8043-5869
Harvard University · USDana-Farber Cancer Institute · USHoward Hughes Medical Institute · US

Funding

PHD TRAINING IN NEUROSCIENCET32MH020017 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JOHN ASSAD · 1997 to 2026
$15.8M
Epigenetic Regulation of Cortical Neuronal Lineage ProgressionR01NS102228 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HARWELL, COREY C · 2017 to 2021
$1.9M
Temporal Specification of Basal Forebrain CircuitryR01MH119156 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HARWELL, COREY C · 2020 to 2023
$1.9M
Temporal Specification of Basal Forebrain CircuitryR56MH119156 · NIMH · HARVARD MEDICAL SCHOOL · PI HARWELL, COREY C · 2019 to 2019
$501k
NIMH NIH HHS R01 MH119156NIMH NIH HHS R56 MH119156NIMH NIH HHS T32 MH020017NINDS NIH HHS R01 NS102228
6 · The paper itself

Abstract

The mammalian cortex is populated by neurons derived from neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from the dorsal telencephalon, whereas inhibitory interneurons are generated in its ventral portion. The transcriptional regulator PRDM16 is expressed by radial glia, neural progenitors present in both regions; however, its mechanisms of action are still not fully understood. It is unclear whether PRDM16 plays a similar role in neurogenesis in both dorsal and ventral progenitor lineages and, if so, whether it regulates common or unique networks of genes. Here, we show that

Indexed as

AnimalsCerebral CortexDNA-Binding ProteinsGABAergic NeuronsInterneuronsMiceNeural Stem CellsTranscription FactorsDNA-Binding ProteinsPrdm16 protein, mouseTranscription FactorsCNS developmentCortical interneuronsMedial ganglionic eminenceNeural progenitorsPrdm16

Identifiers

PMID33060132
PMCPMC7687860
OpenAlexW3092887357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.