ArticleCancer discovery2021
Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin.
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Article in Cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
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Who cites it
82 citing papers in PubMed, 126 citations in OpenAlex.
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- Transcriptomic landscape of transposable elements revealsGenome research · 2026Article
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- Targeting KRAS Inhibitor-Resistant Pancreatic Cancer with an MUC1-C Antibody-Drug Conjugate.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Comparative analysis of single-stranded and non-canonical DNA formation in human and other ape cells with telomere-to-telomere genomes.bioRxiv : the preprint server for biology · 2025Article
- DNA methylation profile to aid in the diagnosis of pancreatic ductal adenocarcinoma and its role in disease progression.Epigenomics · 2025Review
- Innate immune sensing and signaling: Co-opted for genome surveillance? Implications for tumorigenesis.DNA repair · 2025Review
- Epigenetic evolution and clinicopathological implications of distinct DNA methylation profiles in pancreatic ductal adenocarcinoma.Scientific reports · 2025Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
38 authors at 8 institutions in 6 countries.
Elisa EspinetHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany. a.trumpp@dkfz.de e.espinet@dkfz.de.ORCID 0000-0002-0690-9878
Zuguang Gu *Bioinformatics and Omics Data Analytics, DKFZ, Heidelberg, Germany.
Charles D Imbusch *Division of Applied Bioinformatics, DKFZ and NCT, Heidelberg, Germany.ORCID 0000-0003-4920-551X
Nathalia A GieseDepartment of General and Visceral Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Magdalena BüscherHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.ORCID 0000-0002-2215-3329
Mariam SafaviHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
Silke WeisenburgerHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
Corinna KleinHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
Vanessa VogelHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
Mattia FalconeHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.ORCID 0000-0003-0906-5735
Jacob Insua-RodríguezHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
Manuel ReitbergerHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
Vera ThielHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
Steffi O KossiHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
Alexander MuckenhuberInstitute of Pathology, Technical University of Munich, Munich, Germany.
Karnjit SaraiDepartment of Cellular and Physiological Sciences, Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Alex Y L LeeDepartment of Cellular and Physiological Sciences, Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Elyne BackxLaboratory of Molecular and Medical Oncology, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0003-4699-6248
Soheila ZareiDepartment of Cellular and Physiological Sciences, Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Matthias M GaidaInstitute of Pathology, University Hospital of Heidelberg, Heidelberg, Germany.
Manuel Rodríguez-ParedesDivision of Epigenetics, DKFZ-ZMBH Alliance, DKFZ, Heidelberg, Germany.
Elisa DonatoHI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.ORCID 0000-0003-3541-9170
Hsi-Yu YenInstitute of Pathology, Technical University of Munich, Munich, Germany.
Roland EilsHeidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.
Matthias SchlesnerBioinformatics and Omics Data Analytics, DKFZ, Heidelberg, Germany.ORCID 0000-0002-5896-4086
Nicole PfarrInstitute of Pathology, Technical University of Munich, Munich, Germany.ORCID 0000-0002-5977-5375
Thilo HackertDepartment of General and Visceral Surgery, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0002-7012-1196
Christoph PlassDivision of Cancer Epigenomics, DKFZ, Heidelberg, Germany.ORCID 0000-0003-2554-3952
Benedikt BrorsGerman Cancer Consortium (DKTK), Heidelberg, Germany.ORCID 0000-0001-5940-3101
Katja SteigerGerman Cancer Consortium (DKTK), Heidelberg, Germany.ORCID 0000-0002-7269-5433
Dieter WeichenhanHeidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.
H Efsun ArdaLaboratory of Receptor Biology and Gene Expression, Center of Cancer Research, NCI, NIH, Bethesda, Maryland.
Ilse RoomanLaboratory of Molecular and Medical Oncology, Vrije Universiteit Brussel, Brussels, Belgium.
Janel L KoppDepartment of Cellular and Physiological Sciences, Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Oliver StrobelDepartment of General and Visceral Surgery, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0001-5100-8449
Wilko WeichertGerman Cancer Consortium (DKTK), Heidelberg, Germany.
Martin R Sprick *HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.ORCID 0000-0001-9691-7574
Andreas Trumpp *HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany. a.trumpp@dkfz.de e.espinet@dkfz.de.ORCID 0000-0002-6212-3466
German Cancer Research Center · DEHeidelberg University · DEUniversity of British Columbia · CAHeidelberg Institute for Stem Cell Technology and Experimental Medicine · DETechnical University of Munich · DEVrije Universiteit Brussel · BEJohannes Gutenberg University Mainz · DEOffice of Extramural Research · US
Funding
Identification of genomic regulatory elements in pancreas cellsZIABC011798 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ARDA, HATICE · 2018 to 2025
$10.5MCIHRIntramural NIH HHS ZIA BC011798
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia, which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified epithelial cells from human PDAC and normal pancreas and derived their genome-wide transcriptome and DNA methylome landscapes. Clustering based on DNA methylation revealed two distinct PDAC groups displaying different methylation patterns at regions encoding repeat elements. Methylation
Indexed as
DNA MethylationRepetitive Sequences, Nucleic AcidCarcinoma, Pancreatic DuctalCell Transformation, NeoplasticCpG IslandsDisease ProgressionDisease SusceptibilityGene Expression ProfilingGene Expression Regulation, NeoplasticHumansInterferonsModels, BiologicalPancreatic NeoplasmsPrognosisReproducibility of ResultsSignal TransductionInterferons
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