Evidence map›Paper›PMID 33060092›Full record

ArticleBMJ open2020

Cluster-randomised trial of community-based screening for eye disease in adults in Nepal: the Village-Integrated Eye Worker Trial II (VIEW II) trial protocol.

Kieran S O'Brien, Valerie M Stevens, Raghunandan Byanju, Ram Prasad Kandel, Gopal Bhandari, Sadhan Bhandari, Jason S Melo, Travis C Porco, Thomas M Lietman, Jeremy D Keenan and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03752840 (Village-Integrated Eye Worker Trial II), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03752840 narecruitingnot on this map

Village-Integrated Eye Worker Trial II (VIEW II):A Cluster-randomized Trial of the Effectiveness of Community-based Ocular Disease Screening

TypeinterventionalSponsorUniversity of California, San FranciscoRan2019 to 2029Enrolled60,200ConditionsAge-related Macular Degeneration, Diabetic Retinopathy, GlaucomaArmsVisual acuity (presenting and pinhole), Optical coherence tomography (OCT), Intraocular pressure, Active linkage to care, Fundus Photography
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Research Progress of Diabetes-related Glaucoma: Mechanisms, Impacts and Management Strategies.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Kieran S O'BrienFrancis I Proctor Foundation, University of California San Francisco, San Francisco, California, USA.
Valerie M StevensFrancis I Proctor Foundation, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0003-4482-2519
Raghunandan ByanjuBharatpur Eye Hospital, Bharatpur, Nepal.
Ram Prasad KandelSeva Foundation, Bharatpur, Nepal.
Gopal BhandariBharatpur Eye Hospital, Bharatpur, Nepal.
Sadhan BhandariBharatpur Eye Hospital, Bharatpur, Nepal.
Jason S MeloFrancis I Proctor Foundation, University of California San Francisco, San Francisco, California, USA.
Travis C PorcoFrancis I Proctor Foundation, University of California San Francisco, San Francisco, California, USA.
Thomas M LietmanFrancis I Proctor Foundation, University of California San Francisco, San Francisco, California, USA.
Jeremy D KeenanFrancis I Proctor Foundation, University of California San Francisco, San Francisco, California, USA jeremy.keenan@ucsf.edu.ORCID 0000-0002-7118-1457
Group Information for the VIEW II Study Group
University of California, San Francisco · USBiratnagar Eye Hospital · NP

Funding

Village-Integrated Eye Worker trial II (VIEW II)UG1EY028097 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KEENAN, JEREMY DAVID · 2018 to 2023
$2.9M
NEI NIH HHS UG1 EY028097
6 · The paper itself

Abstract

introductionThe majority of blindness worldwide could be prevented or reversed with early diagnosis and treatment, yet identifying at-risk and prevalent cases of eye disease and linking them with care remain important obstacles to addressing this burden. Leading causes of blindness like glaucoma, diabetic retinopathy and age-related macular degeneration have detectable early asymptomatic phases and can cause irreversible vision loss. Mass screening for such diseases could reduce visual impairment at the population level. METHODS AND ANALYSIS: This protocol describes a parallel-group cluster-randomised trial designed to determine whether community-based screening for glaucoma, diabetic retinopathy and age-related macular degeneration reduces population-level visual impairment in Nepal. A door-to-door population census is conducted in all study communities. All adults aged ≥60 years have visual acuity tested at the census visit, and those meeting referral criteria are referred to a local eye care facility for further diagnosis and management. Communities are subsequently randomised to a community-based screening programme or to no additional intervention. The intervention consists of a single round of screening including intraocular pressure and optical coherence tomography assessment of all adults ≥60 years old with enhanced linkage to care for participants meeting referral criteria. Four years after implementation of the intervention, masked outcome assessors conduct a repeat census to collect data on the primary outcome, visual acuity. Individuals with incident visual impairment receive a comprehensive ophthalmological examination to determine the cause of visual impairment. Outcomes are compared by treatment arm according to the originally assigned intervention. ETHICS AND DISSEMINATION: The trial has received ethical approval from the University of California San Francisco Institutional Review Board, Nepal Netra Jyoti Sangh and the Nepal Health Research Council. Results of this trial will be disseminated through publication in peer-reviewed journals and presentation at local and international meetings. TRIAL REGISTRATION NUMBER: NCT03752840.

Indexed as

Mass ScreeningVision, LowAdultAgedHumansMiddle AgedNepalRandomized Controlled Trials as TopicSan Franciscoage-related macular degenerationdiabetic retinopathyglaucomamass screeningrandomised controlled trial

Identifiers

PMID33060092
PMCPMC7566737
OpenAlexW3093347532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.