ArticleLipids in health and disease2020
A dose-independent association of triglyceride levels with all-cause mortality among adults population.
Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Targeting triglycerides for cardiovascular risk reduction.Internal and emergency medicine · 2026Review
- Triglyceride levels and all-cause mortality in patients with left main coronary artery disease undergoing percutaneous coronary intervention.Frontiers in cardiovascular medicine · 2026Article
- Impact of lipid profiles and risk factors on all-cause mortality in males and females: insights from a Turkish cohort study.Open medicine (Warsaw, Poland) · 2026Article
- Mortality Risk of Sarcopenia and Malnutrition in Older Patients with Type 2 Diabetes Mellitus.Nutrients · 2025Article
- Association of Lipid Profile With Cardiovascular Diseases and All-Cause Death: A 2-Decade Follow-Up of the Tehran Lipid and Glucose Study.Journal of the American Heart Association · 2025Article
- Application of the Weibull Model to Statins for Triglyceride Management in Patients With Hyperlipidaemia.Pharmacology research & perspectives · 2025Article
- Shorter-term and longer-term mortality prediction in the Australian Diabetes, Obesity and Lifestyle (AusDiab) study.Internal medicine journal · 2025Article
- Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure.Nature communications · 2025Article
- Call for a consensual definition of dyslipidemia in coronary angiography trials.Frontiers in cardiovascular medicine · 2025Review
- Fasting Triglycerides in the Upper Normal Range Are Independently Associated with an Increased Risk of Diabetes Mortality in a Large Representative US Population.Journal of cardiovascular development and disease · 2024Article
- Sodium Replacement with KCl and MSG: Attitudes, Perception and Acceptance in Reduced Salt Soups.Foods (Basel, Switzerland) · 2023Article
- Associations of Hypertriglyceridemia Onset Age With Cardiovascular Disease and All-Cause Mortality in Adults: A Cohort Study.Journal of the American Heart Association · 2022Article
- Fasting status modifies the association between triglyceride and all-cause mortality: A cohort study.Health science reports · 2022Article
- The Triglyceride-Glucose Index, an Insulin Resistance Marker, Was Non-linear Associated With All-Cause and Cardiovascular Mortality in the General Population.Frontiers in cardiovascular medicine · 2020Article
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe relationship between triglyceride (TG) level and the mortality risk of all-cause and cardiovascular disease is not entirely consistent among adults.
methodsThe present analysis included adult participants from National Health and Nutrition Examination Surveys (NHANES) between the periods 1999-2014. The levels of TG were categorized into < 150, 150-199, 200-250 and ≥ 250 mg/dL respectively. Multivariate Cox regression analysis, stratified analysis and generalized additive model were conducted to reveal the correlation between TG and mortality risk. Results were presented in hazard ratio (HRs) and 95% confidence intervals (CIs).
resultsThere were 18,781 (9130 males, mean age was 45.64 years) participants being included in the analysis. The average follow-up period was 8.25 years, where 1992 (10.61%) cases of all-cause and 421 (2.24%) cardiovascular death have occurred. In the multivariate Cox model, every 1 mg/dL raise in TG has significantly associated with all-cause mortality (HR: 1.08, 95% CI: 1.02, 1.15) but not cardiovascular mortality (HR: 1.10, 95% CI: 0.97, 1.24). When using TG < 150 mg/dL as reference, TG ≥ 250 mg/dL associated with death from all-cause (HR = 1.34, 95% CI: 1.12, 1.60; P = 0.0016 but not cardiovascular death (HR = 1.26, 95% CI: 0.85, 1.88; P = 0.2517). According to smoothing spline plots, the risk of all-cause was the lowest when TG was approximately 135 mg/dL.
conclusionTG might have a dose-independent association with all-cause mortality among adults in United States.
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