ArticleTherapeutic advances in respiratory disease
Bronchiectasis and increased mortality in patients with corticosteroid-dependent severe asthma: a nationwide population study.
Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Mortality Among Adults with Subspecialist-Treated Severe Asthma: A Descriptive Analysis from the Observational CHRONICLE Study.Journal of asthma and allergy · 2026Article
- Risk of Stroke in COVID-19 Survivors With Asthma: A Nationwide, Population-Based Cohort Study.Journal of Korean medical science · 2025Article
- Effects of Vaccination on Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Cohort Study.Tuberculosis and respiratory diseases · 2025Article
- Chronic obstructive pulmonary disease is a risk factor for non-tuberculous mycobacterial pulmonary disease: a population-based matched cohort study.BMJ open respiratory research · 2025Article
- Exacerbation and mortality risk in individuals with bronchiectasis post-COVID-19 recovery.ERJ open research · 2025Article
- Phenotypes and endotypes in bronchiectasis: a narrative review of progress toward precision medicine.Journal of thoracic disease · 2025Review
- Risk of acute exacerbation of chronic obstructive pulmonary disease after COVID-19 recovery: a nationwide population-based cohort study.Respiratory research · 2025Article
- Article
- COVID-19 and risk of long-term mortality in COPD: a nationwide population-based cohort study.BMJ open respiratory research · 2025Article
- Association between rheumatoid arthritis and interstitial lung disease and impact of serologic status: a large-scale longitudinal study.Scientific reports · 2025Article
- Impact of physical activity on all-cause mortality in individuals with non-cystic fibrosis bronchiectasis.Frontiers in medicine · 2025Article
- Secondary Immunodeficiency and Non-cystic Fibrosis Bronchiectasis.Tuberculosis and respiratory diseases · 2024Article
- Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: a 10-year Korean national cohort study.ERJ open research · 2024Article
- The Impact of Bronchiectasis on the Clinical Characteristics of Non-Severe Asthma.Allergy, asthma & immunology research · 2024Article
- Bacteria and viruses and clinical outcomes of asthma-bronchiectasis overlap syndrome: A cohort study.Clinical and translational allergy · 2024Article
- Management of comorbidities in difficult and severe asthma.Breathe (Sheffield, England) · 2023Review
- Impact of air pollution on healthcare utilization in patients with bronchiectasis.Frontiers in medicine · 2023Article
- Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study.Scientific reports · 2022Article
- Association between Smoking Status and Incident Non-Cystic Fibrosis Bronchiectasis in Young Adults: A Nationwide Population-Based Study.Journal of personalized medicine · 2022Article
- Female Reproductive Factors and the Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study.Biomedicines · 2022Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term corticosteroid (CS) use is associated with increased mortality in patients with asthma, and comorbid bronchiectasis is also associated with frequent asthma exacerbation and increased healthcare use. However, there is limited information on whether bronchiectasis further increases mortality in patients with CS-dependent asthma. This study examined the impact of bronchiectasis on mortality in patients with CS-dependent asthma.
methodsA retrospective cohort of patients with CS-dependent asthma ⩾18 years old was established using records from the Korean National Health Insurance Service database from 2005 to 2015. Patients with CS-dependent asthma with and without bronchiectasis were matched by age, sex, type of insurance, and Charlson comorbidity index. We evaluated the hazard ratio (HR) for all-cause mortality in patients with bronchiectasis compared with those without bronchiectasis.
resultsThe study cohort included 754 patients with CS-dependent asthma with bronchiectasis and 3016 patients with CS-dependent asthma without bronchiectasis. Patients with CS-dependent asthma with bronchiectasis had a higher all-cause mortality than those without bronchiectasis (8429/100,000
conclusionsBronchiectasis further increases all-cause mortality in patients with CS-dependent asthma, a trend that was especially associated with respiratory diseases including chronic obstructive pulmonary disease. Strategies to improve treatment outcomes in patients with CS-dependent asthma with bronchiectasis are urgently needed to improve long-term survival.The reviews of this paper are available via the supplemental material section.
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