Evidence map›Paper›PMID 33059312›Full record

ArticleRedox biology2020

NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation.

Emily Stenke, Gabriella Aviello, Ashish Singh, Sean Martin, Des Winter, Brian Sweeney, Michael McDermott, Billy Bourke, Seamus Hussey, Ulla G Knaus

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Dynamic regulation of receptor-modulated endothelial NADPH oxidases.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. De novo DUOX2 expression in neutrophil subsets shapes the pathogenesis of intestinal disease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Emerging Pathological Engagement of Ferroptosis in Gut Diseases.Oxidative medicine and cellular longevity · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Emily StenkeConway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
Gabriella AvielloConway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
Ashish SinghConway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
Sean MartinSt. Vincent's University Hospital, Dublin, Ireland.
Des WinterSt. Vincent's University Hospital, Dublin, Ireland.
Brian SweeneyNational Children's Research Centre, Children's Health Ireland, Dublin, Ireland.
Michael McDermottNational Children's Research Centre, Children's Health Ireland, Dublin, Ireland.
Billy BourkeConway Institute, School of Medicine, University College Dublin, Dublin, Ireland; National Children's Research Centre, Children's Health Ireland, Dublin, Ireland.
Seamus HusseyNational Children's Research Centre, Children's Health Ireland, Dublin, Ireland; RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Ulla G KnausConway Institute, School of Medicine, University College Dublin, Dublin, Ireland; National Children's Research Centre, Children's Health Ireland, Dublin, Ireland. Electronic address: ulla.knaus@ucd.ie.
University College Dublin · IENational Children’s Research Centre · IESt. Vincent's University Hospital · IEChildren's Health Ireland at Crumlin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulated redox signaling and oxidative injury are associated with inflammatory processes and fibrosis. H

Indexed as

MyofibroblastsNADPH OxidasesAnimalsFibrosisHumansHydrogen PeroxideInflammationMiceNADPH Oxidase 4Hydrogen PeroxideNADPH Oxidase 4NADPH OxidasesCrohn's diseaseFibrosisIntestinal inflammationNADPH oxidaseNOX4

Identifiers

PMID33059312
PMCPMC7567035
OpenAlexW3092607550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.