Evidence map›Paper›PMID 33059224›Full record

ArticleJournal of affective disorders2021

The Structure of Executive Dysfunction in Depression and Anxiety.

Stacie L Warren, Wendy Heller, Gregory A Miller

Abstract read
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  8. Executive Functioning as a Pathway Between Social Skills and Psychopathology: The Moderating Role of Autism Diagnosis.Autism research : official journal of the International Society for Autism Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stacie L WarrenPalo Alto University, Department of Psychology, 1791 Arastradero Road, Palo Alto, CA 94304; University of Illinois at Urbana-Champaign, Department of Psychology, 603 E. Daniel Street, Champaign, IL 61820. Electronic address: swarren@paloaltou.edu.
Wendy HellerUniversity of Illinois at Urbana-Champaign, Department of Psychology, 603 E. Daniel Street, Champaign, IL 61820.
Gregory A MillerUniversity of Illinois at Urbana-Champaign, Department of Psychology, 603 E. Daniel Street, Champaign, IL 61820; University of California, Los Angeles, Department of Psychology, 1285 Franz Hall, 951563.

Funding

Proj 5: Early Development (224-250)P50MH079485 · NIMH · UNIVERSITY OF COLORADO · PI O'REILLY, RANDALL CHARLES · 2008 to 2012
$8.7M
MECHANISMS OF ATTENTIONAL BIAS IN PSYCHOPATHOLOGYR01MH061358 · NIMH · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HELLER, WENDY · 2000 to 2009
$2.6M
TRAINING IN COGNITIVE PSYCHOPHYSIOLOGYT32MH019554 · NIMH · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HELLER, WENDY · 1992 to 2012
$2.3M
NIMH NIH HHS P50 MH079485NIMH NIH HHS R01 MH061358NIMH NIH HHS T32 MH019554
6 · The paper itself

Abstract

backgroundAlthough research has demonstrated that depression and anxiety are associated with problematic executive function (EF), results are often inconsistent and underspecified. Delineating specific EF impairments in depression and anxiety has the potential to provide a mechanistic account of symptom presentation and course in these highly co-occurring disorders. The present study evaluated associations between components of EF and symptom dimensions of depression (depressed mood) and anxiety (anxious apprehension, anxious arousal) using factor analyses and structural equation modeling.

methodsUndergraduates (N = 1,123) completed self-report measures of EF in everyday life and of psychopathology. Based on a three-factor model (Miyake et al., 2000), item-level exploratory (n = 561) and confirmatory (n = 562) factor analyses were conducted on inhibition, shifting, and working memory scales chosen from the EF measure. Structural equation modeling tested the relationship of EF factors to dimensions of psychopathology using the total sample.

resultsA three-factor model of EF best fit the data and was replicated via confirmatory factor analysis. Depressed mood and anxious arousal evidenced broad deficits across all EF domains, whereas anxious apprehension evidenced shifting disruptions. LIMITATIONS: Perceived EF may not index the same constructs as performance-based EF tests. Further, the present study was restricted to college students, warranting replication in other samples.

conclusionsFindings suggest that depressed mood and anxious arousal are characterized by a general disruption in the ability to maintain task goals, whereas anxious apprehension is characterized by cognitive inflexibility. EF impairments are likely contributory factors in the maintenance of affective disorders.

Indexed as

Cognitive DysfunctionDepressionAnxietyAnxiety DisordersExecutive FunctionHumansaffectarousalexecutive functionfactor analysislatent class analysispsychopathology

Identifiers

PMID33059224
PMCPMC7738359

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.