ReviewMolecular and cellular endocrinology2021
Stem cell function and plasticity in the normal physiology of the adrenal cortex.
Review in Molecular and cellular endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Adrenal rather than central dysfunction limits hypothalamic-pituitary-adrenal axis recovery after chronic glucocorticoid treatment in male mice.Endocrinology · 2026Article
- The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion.Nature communications · 2026Article
- Adrenocortical stem cells in health and disease.Nature reviews. Endocrinology · 2025Review
- Sexual dimorphism in benign adrenocortical tumours.European journal of endocrinology · 2025Review
- Exploration of the potential of genomic editing in the treatment of congenital adrenal hyperplasia.Frontiers in endocrinology · 2025Review
- Analysis of Cancer Stem Cell Markers in Various Histological Subtypes of Adrenocortical Cancer.Current issues in molecular biology · 2024Article
- Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production.bioRxiv : the preprint server for biology · 2024Article
- Proteomic profiling of the extracellular matrix in the human adrenal cortex.Matrix biology plus · 2024Article
- An integrated single-cell analysis of human adrenal cortex development.JCI insight · 2023Article
- Models of Congenital Adrenal Hyperplasia for Gene Therapies Testing.International journal of molecular sciences · 2023Review
- Development and function of the fetal adrenal.Reviews in endocrine & metabolic disorders · 2023Review
- [Adrenal glands stem cells: general signaling pathways].Problemy endokrinologii · 2021Article
- Review
- Cellular Senescence in Human Aldosterone-Producing Adrenocortical Cells and Related Disorders.Biomedicines · 2021Article
- Epithelial and Mesenchymal Markers in Adrenocortical Tissues: How Mesenchymal Are Adrenocortical Tissues?Cancers · 2021Article
- The Genotype-Based Morphology of Aldosterone-Producing Adrenocortical Disorders and Their Association with Aging.Endocrinology and metabolism (Seoul, Korea) · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The adrenal cortex functions to produce steroid hormones necessary for life. To maintain its functional capacity throughout life, the adrenal cortex must be continually replenished and rapidly repaired following injury. Moreover, the adrenal responds to endocrine-mediated organismal needs, which are highly dynamic and necessitate a precise steroidogenic response. To meet these diverse needs, the adrenal employs multiple cell populations with stem cell function. Here, we discuss the literature on adrenocortical stem cells using hematopoietic stem cells as a benchmark to examine the functional capacity of particular cell populations, including those located in the capsule and peripheral cortex. These populations are coordinately regulated by paracrine and endocrine signaling mechanisms, and display remarkable plasticity to adapt to different physiological and pathological conditions. Some populations also exhibit sex-specific activity, which contributes to highly divergent proliferation rates between sexes. Understanding mechanisms that govern adrenocortical renewal has broad implications for both regenerative medicine and cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.