Evidence map›Paper›PMID 33058756›Full record

ArticleCell2020

A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

Lifeng Wang, Nasa Sinnott-Armstrong, Alexandre Wagschal, Abigail R Wark, Joao-Paulo Camporez, Rachel J Perry, Fei Ji, Yoojin Sohn, Justin Oh, Su Wu and 22 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 75 citations in OpenAlex.

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  12. Neanderthal adaptive introgression shapedProceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 9 institutions in 4 countries.

Lifeng WangMassachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Nasa Sinnott-ArmstrongBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alexandre WagschalMassachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Abigail R WarkDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Joao-Paulo CamporezDepartments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.
Rachel J PerryDepartments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.
Fei JiDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Yoojin SohnMassachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Justin OhMassachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Su WuMassachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Jessica CheryMassachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Bahareh Nemati MoudElse Kroener-Fresenius-Center of Nutritional Medicine, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.
Alham SaadatBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Simon N DankelMohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, 5020 Bergen, Norway.
Gunnar MellgrenMohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, 5020 Bergen, Norway.
Divya Sri Priyanka TallapragadaMohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, 5020 Bergen, Norway.
Sophie Madlen StrobelBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, 80992 Munich, Germany.
Mi-Jeong LeeObesity Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Ryan TewheyCenter for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Pardis C SabetiBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Anne SchaeferFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Andreas PetriCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, 2450 Copenhagen, Denmark.
Sakari KauppinenCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, 2450 Copenhagen, Denmark.
Raymond T ChungLiver Center, Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Alexander SoukasBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
Joseph AvruchDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA; Diabetes unit, Medical Services, Massachusetts General Hospital, Boston, MA 02114, USA.
Susan K FriedObesity Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Hans HaunerElse Kroener-Fresenius-Center of Nutritional Medicine, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, 80992 Munich, Germany.
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Gerald I ShulmanDepartments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.
Melina ClaussnitzerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Anders M NäärMassachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: naar@berkeley.edu.
Harvard University · USBroad Institute · USHaukeland University Hospital · NOYale University · USAalborg University · DKBoston University · USFresenius (Germany) · DEMassachusetts General Hospital · USAllen Institute for Brain Science · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Richard A Flavell · 1993 to 2026
$44.0M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
Transcription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YASMIN L. HURD · 2019 to 2026
$16.5M
The reprogramming of limb progenitor cellsR01HD032443 · NICHD · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CLIFFORD J. TABIN · 1995 to 2026
$4.6M
Development of Controlled Release Mitochondrial Protonophore (CRMP) as a Novel Treatment for Type-2 Diabetes and Non-Alcoholic Steatohepatitis in Dysmetabolic Non-Human PrimatesR01DK119968 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2019 to 2024
$2.7M
Regulation of cholesterol/lipid homeostasis by microRNA-33a/bR01DK094184 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NAAR, ANDERS M · 2011 to 2015
$2.5M
Microbiome origins and insulin regulatory responses of the short chain fatty acid acetateR01DK114793 · NIDDK · YALE UNIVERSITY · PI GOODMAN, ANDREW L, SHULMAN, GERALD I · 2018 to 2021
$2.4M
Control of neuron activity and animal behavior by non-coding RNAsR01NS091574 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE · 2015 to 2018
$1.7M
Glucagon Regulation of Hepatic Mitochondrial Activity and Glucose Metabolism by InsP3R-1R01DK116774 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2018 to 2021
$1.7M
NCATS NIH HHS UL1 TR001863NHGRI NIH HHS K99 HG008179NICHD NIH HHS R01 HD032443NIDA NIH HHS P01 DA047233NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK045735NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK094184NIDDK NIH HHS R01 DK114277NIDDK NIH HHS R01 DK114793NIDDK NIH HHS R01 DK116774NIDDK NIH HHS R01 DK119968NINDS NIH HHS R01 NS091574
6 · The paper itself

Abstract

Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also associated with obesity and type 2 diabetes in humans, raising the possibility that additional genetic elements in the locus may have contributed to evolutionary adaptation to famine by promoting energy storage, but which now confer susceptibility to metabolic diseases. We show here that the miR-128-1 microRNA, located at the center of the positively selected locus, represents a crucial metabolic regulator in mammals. Antisense targeting and genetic ablation of miR-128-1 in mouse metabolic disease models result in increased energy expenditure and amelioration of high-fat-diet-induced obesity and markedly improved glucose tolerance. A thrifty phenotype connected to miR-128-1-dependent energy storage may link ancient adaptation to famine and modern metabolic maladaptation associated with nutritional overabundance.

Indexed as

Adipocytes, BrownAdiposityAllelesAnimalsCell DifferentiationCell LineCells, CulturedDiet, High-FatEnergy MetabolismEpigenesis, GeneticGenetic LociGlucoseHomeostasisHumansHypertrophyInsulin ResistanceGlucoseLeptinMicroRNAsMIRN128 microRNA, humanOligonucleotides

Identifiers

PMID33058756
PMCPMC8092355
OpenAlexW3092932915

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.