Evidence map›Paper›PMID 33058732›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

Opsin 3-G

Amy D Wu, William Dan, Yi Zhang, Shruti Vemaraju, Brian A Upton, Richard A Lang, Ethan D Buhr, Dan E Berkowitz, George Gallos, Charles W Emala and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. OGR1-dependent regulation of the allergen-induced asthma phenotype.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Enlightening Ways to Relax Airway Smooth Muscle: Opsins.American journal of respiratory cell and molecular biology · 2021
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Amy D WuDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.ORCID 0000-0003-4983-2724
William DanDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Yi ZhangDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Shruti VemarajuThe Visual Systems Group, Abrahamson Pediatric Eye Institute.
Brian A UptonThe Visual Systems Group, Abrahamson Pediatric Eye Institute.
Richard A LangThe Visual Systems Group, Abrahamson Pediatric Eye Institute.
Ethan D BuhrDepartment of Ophthalmology, University of Washington Medical School, Seattle, Washington; and.
Dan E BerkowitzDepartment of Anesthesiology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
George GallosDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Charles W EmalaDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Peter D YimDepartment of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Columbia University · USCincinnati Children's Hospital Medical Center · USNational Student Clearinghouse Research Center · USUniversity of Alabama at Birmingham · USUniversity of Washington Medical Center · US

Funding

Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
ANESTHESIOLOGY RESEARCH TRAININGT32GM008464 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHARLES W EMALA, May Hua · 1992 to 2026
$6.0M
Neuromuscular blocker-induced asthma during anesthesiaR01GM065281 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2003 to 2018
$5.4M
Novel nutriceuticals relax airway smooth muscle and decrease inflammation in allergic lung diseaseR01HL144852 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2020 to 2023
$1.9M
Calcium activated chloride channel modulation of myometrial excitabilityR01HD082251 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2016 to 2020
$1.6M
Targeting airway smooth muscle chloride fluxes for bronchorelaxationR01HL122340 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2015 to 2018
$1.6M
Mechanisms and Modulation of Opsin 3 Mediated Airway Smooth Muscle RelaxationK08HL150314 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YIM, PETER D · 2021 to 2025
$827k
NHLBI NIH HHS K08 HL150314NHLBI NIH HHS R01 HL122340NHLBI NIH HHS R01 HL144852NICHD NIH HHS R01 HD082251NIGMS NIH HHS R01 GM065281NIGMS NIH HHS T32 GM008464NIGMS NIH HHS T32 GM063483
6 · The paper itself

Abstract

Recently, we characterized blue light-mediated relaxation (photorelaxation) of airway smooth muscle (ASM) and implicated the involvement of opsin 3 (OPN3), an atypical opsin. In the present study, we characterized the cellular signaling mechanisms of photorelaxation. We confirmed the functional role of OPN3 in blue light photorelaxation using trachea from OPN3 null mice (maximal relaxation 52 ± 13% compared with wild-type mice 90 ± 4.3%,

Indexed as

AnimalsCells, CulturedCyclic AMPCyclic AMP-Dependent Protein KinasesG-Protein-Coupled Receptor Kinase 2HumansMaleMiceMice, Inbred C57BLMuscle RelaxationMuscle, SmoothMyocytes, Smooth MuscleOpsinsRod OpsinsSignal TransductionTracheaCyclic AMPCyclic AMP-Dependent Protein KinasesG-Protein-Coupled Receptor Kinase 2GRK2 protein, mouseOPN3 protein, mouseOpsinsRod Opsinsblue lightnonvisual opsinOPN1LWOPN3photorelaxation

Identifiers

PMID33058732
PMCPMC7780995
OpenAlexW3092935658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.