Evidence map›Paper›PMID 33058513›Full record

ArticleJournal of diabetes investigation2021

Association of time in range with hemoglobin A1c, glycated albumin and 1,5-anhydro-d-glucitol.

Mana Ohigashi, Keiko Osugi, Yoshiki Kusunoki, Kahori Washio, Satoshi Matsutani, Taku Tsunoda, Toshihiro Matsuo, Kosuke Konishi, Tomoyuki Katsuno, Mitsuyoshi Namba and 1 more

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Glycated Albumin Correlates With Time-in-Range Better Than HbA1c or Fructosamine.The Journal of clinical endocrinology and metabolism · 2023
    Article
  11. Article
  12. Review
  13. Relationship Between Time in Range and Dusk Phenomenon in Outpatients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Article
  14. Significance of Glycemic Variability in Diabetes Mellitus.Internal medicine (Tokyo, Japan) · 2022
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mana OhigashiDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.ORCID https://orcid.org/0000-0002-1420-9337
Keiko OsugiDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Yoshiki KusunokiDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.ORCID https://orcid.org/0000-0002-9361-9317
Kahori WashioDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Satoshi MatsutaniDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Taku TsunodaDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Toshihiro MatsuoDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Kosuke KonishiDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Tomoyuki KatsunoDepartment of Occupational Therapy, School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Hyogo, Japan.
Mitsuyoshi NambaDepartment of Diabetes Mellitus, Takarazuka City Hospital, Takarazuka, Hyogo, Japan.
Hidenori KoyamaDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Hyogo Medical University · JPHyogo University of Health Sciences · JPTakarazuka City Hospital · JP

Funding

Hyogo College of Medicine 210790
6 · The paper itself

Abstract

AIMS/

introductionHemoglobin A1c (HbA1c), glycated albumin (GA) and 1,5-anhydro-d-glucitol (1,5-AG) are used as indicators of glycemic control, whereas continuous glucose monitoring (CGM) is used to assess daily glucose profiles. The aim of this study was to investigate the relationships between CGM metrics, such as time in range (TIR), and glycemic control indicators. MATERIALS AND

methodsWe carried out retrospective CGM and blood tests on 189 outpatients with impaired glucose tolerance (n = 22), type 1 diabetes mellitus (n = 67) or type 2 diabetes mellitus (n = 100).

resultsIn type 1 diabetes mellitus and type 2 diabetes mellitus patients, HbA1c and GA were negatively correlated with TIR, whereas 1,5-AG was positively correlated with TIR. In type 1 diabetes mellitus patients, a TIR of 70% corresponded to HbA1c, GA and 1,5-AG of 6.9% (95% confidence interval [CI] 6.5-7.2%), 20.3% (95% CI 19.0-21.7%) and 6.0 µg/mL (95% CI 5.1-6.9 µg/mL), respectively. In type 2 diabetes mellitus patients, a TIR of 70% corresponded to HbA1c, GA and 1,5-AG of 7.1% (95% CI 7.0-7.3%), 19.3% (95% CI 18.7-19.9%) and 10.0 µg/mL (95% CI 9.0-11.0 µg/mL), respectively. TIR values corresponding to HbA1c levels of 7.0% were 56.1% (95% CI 52.3-59.8%) and 74.2% (95% CI 71.3-77.2%) in type 1 diabetes mellitus and type 2 diabetes mellitus patients, respectively.

conclusionsThe results of this study showed that the estimated HbA1c corresponding to a TIR of 70% was approximately 7.0% for both type 1 diabetes mellitus and type 2 diabetes mellitus patients, and that the estimated 1,5-AG calculated from the TIR of 70% might be different between type 1 diabetes mellitus and type 2 diabetes mellitus patients.

Indexed as

AdultAgedBlood Glucose Self-MonitoringDeoxyglucoseDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleGlucose IntoleranceGlucose Metabolism DisordersGlycated HemoglobinGlycated Serum AlbuminGlycation End Products, AdvancedGlycemic ControlHumansMaleMiddle Aged1,5-anhydroglucitolDeoxyglucoseGlycated HemoglobinGlycated Serum AlbuminGlycation End Products, AdvancedSerum AlbuminContinuous glucose monitoringHemoglobin A1cTime in range

Identifiers

PMID33058513
PMCPMC8169363
OpenAlexW3092935433

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.