ReviewHuman brain mapping2021
Hippocampal subfield volumetry from structural isotropic 1 mm
Open access · goldAbstract readReview
In one paragraph
Review in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 4 pooled it
8.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 4 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Unveiling the hippocampal subfield changes across the Alzheimer's disease continuum: a systematic review of neuroimaging studies.Brain imaging and behavior · 2025Pooled it
- Hippocampal subfield volumes in mild cognitive impairment and alzheimer's disease: a systematic review and meta-analysis.Brain imaging and behavior · 2023Pooled it
- A meta-analysis of the relation between hippocampal volume and memory ability in typically developing children and adolescents.Hippocampus · 2022Pooled it
- Hippocampal subfield alterations in schizophrenia and major depressive disorder: a systematic review and network meta-analysis of anatomic MRI studies.Journal of psychiatry & neuroscience : JPNPooled it
- Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults.Neurobiology of aging · 2023Trial
- Impaired autobiographical remembering and future thinking in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2026Article
- Review
- Posttraumatic Stress Disorder Severity-related Accelerated Aging, Hippocampal Volume, and CLDN5 DNA Methylation.Biopsychosocial science and medicine · 2026Article
- Characterizing the MRI signature of hippocampal sclerosis of aging.Alzheimer's research & therapy · 2026Article
- High-resolution MRI evidence for age- and sex-related changes in hippocampal subfield volume during healthy aging.GeroScience · 2026Article
- Diencephalic integrity explains aspects of hippocampal amnesia.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Hippocampal atrophy in untreated de novo Parkinson's disease with obstructive sleep apnea.NPJ Parkinson's disease · 2026Article
- Hippocampal subfield-specific imaging in depression: the translational power of ultra-high field MRI.Translational psychiatry · 2026Review
- Age-related volumetric differences of hippocampal subfields in the developing brain: a retrospective MRI study.Brain structure & function · 2026Article
- Associations among stress perception, clinical symptoms, and hippocampal subfield volumes in first-episode patients with schizophrenia.Frontiers in psychiatry · 2026Article
- Ultra-high field brain MRI for functional neurological disorder: opportunities and challenges.NeuroImage. Clinical · 2026Review
- Hippocampal subregional texture features associated with Alzheimer's disease severity and cognition.Brain communications · 2026Article
- Relationship between hippocampal volume and treatment response before and after escitalopram administration in patients with depression.Translational psychiatry · 2025Article
- Amygdalar and hippocampal volume loss in limbic-predominant age-related TDP-43 encephalopathy.Brain : a journal of neurology · 2025Article
- Automatic Segmentation of Medial Temporal Lobe Subregions in Multi-Scanner, Multi-Modality Magnetic Resonance Imaging of Variable Quality.Hippocampus · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 11 institutions in 5 countries.
Laura E M WisseDiagnostic Radiology, Lund University, Lund, Sweden.ORCID 0000-0001-7504-3943
Gaël ChételatUniversité Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, Caen, France.ORCID 0000-0002-4889-7932
Ana M DaughertyDepartment of Psychology, Wayne State University, Detroit, Michigan, USA.
Robin de FloresUniversité Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, Caen, France.
Renaud la JoieMemory and Aging Center, University of California San Francisco, San Francisco, California, USA.
Susanne G MuellerDepartment of Radiology, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-5515-4432
Craig E L StarkDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA.
Lei WangDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0003-3870-3388
Paul A YushkevichPenn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David BerronClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Naftali RazDepartment of Psychology, Wayne State University, Detroit, Michigan, USA.ORCID 0000-0002-5080-2138
Arnold BakkerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rosanna K OlsenRotman Research Institute, Baycrest Health Sciences, Toronto, Canada.ORCID 0000-0002-2918-4152
Valerie A CarrDepartment of Psychology, San Jose State University, San Jose, California, USA.
Inserm · FRLund University · SEWayne State University · USBaycrest Hospital · CAJohns Hopkins University · USNorthwestern University · USSan Francisco VA Medical Center · USSan Jose State University · USUniversity of California, Irvine · USUniversity of California, San Francisco · USUniversity of Pennsylvania · US
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MNEURAL CORRELATES OF AGE-RELATED DIFFERENCES IN MEMORYR01AG011230 · NIA · WAYNE STATE UNIVERSITY · PI DAUGHERTY, ANA MARIE, RAZ, NAFTALI · 1993 to 2020
$4.8MHigh-resolution Structural and Functional Brain Imaging of the Medial Temporal LoR01AG034613 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI STARK, CRAIG E · 2009 to 2018
$4.6MEx Vivo Imaging of the Aging Brain to Discover Morphology/Pathology AssociationsR01AG056014 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Paul A. Yushkevich · 2017 to 2026
$4.5MA harmonized medial temporal lobe subregion segmentation protocol: an essential element for dementia researchR01AG070592 · NIA · WAYNE STATE UNIVERSITY · PI Ana Marie Daugherty, Rosanna Kathleen Olsen · 2022 to 2026
$3.5MNeurodegenerative and Neurodevelopmental Subcortical Shape DiffeomorphometryR01EB020062 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I, MOSTOFSKY, STEWART H · 2016 to 2019
$2.8MPREDICT-ADFTD: Multimodal Imaging Prediction of AD/FTD and Differential DiagnosisR01AG055121 · NIA · OHIO STATE UNIVERSITY · PI ROSEN, HOWARD J, WANG, LEI · 2017 to 2020
$2.8MImproving the sensitivity and specificity of MRI-based biomarkers in Alzheimer's diseaseRF1AG069474 · NIA · UNIVERSITY OF PENNSYLVANIA · PI WOLK, DAVID A, YUSHKEVICH, PAUL A. · 2021 to 2021
$2.1MNIA NIH HHS P01 AG019724NIA NIH HHS R01 AG011230NIA NIH HHS R01 AG034613NIA NIH HHS R01 AG055121NIA NIH HHS R01 AG056014NIA NIH HHS R01 AG070592NIA NIH HHS RF1 AG069474NIBIB NIH HHS R01 EB020062
Abstract
Spurred by availability of automatic segmentation software, in vivo MRI investigations of human hippocampal subfield volumes have proliferated in the recent years. However, a majority of these studies apply automatic segmentation to MRI scans with approximately 1 × 1 × 1 mm
Indexed as
HippocampusHumansMagnetic Resonance ImagingOrgan Size1 mm3FreeSurferhippocampal subfieldsMRIvolumetry
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.