ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020
Neuronal AMPK coordinates mitochondrial energy sensing and hypoxia resistance in C. elegans.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat stress.Current biology : CB · 2026Article
- Exercise-Induced Differential Transcriptional Output of AMPK Signaling Improves Axon Regeneration and Functional Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Mitochondrial energy state controls AMPK-mediated foraging behavior inScience advances · 2024Article
- The Reduction in the Mitochondrial Membrane Potential in Aging: The Role of the Mitochondrial Permeability Transition Pore.International journal of molecular sciences · 2023Review
- From mitochondria to cells to humans: Targeting bioenergetics in aging and disease.The international journal of biochemistry & cell biology · 2023Article
- Optogenetic rejuvenation of mitochondrial membrane potential extendsNature aging · 2023Article
- A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans.Nature communications · 2022Article
- Site-specific mitochondrial dysfunction in neurodegeneration.Mitochondrion · 2022Article
- An energetics perspective on geroscience: mitochondrial protonmotive force and aging.GeroScience · 2021Article
- Decreased Mitochondrial Membrane Potential Activates the Mitochondrial Unfolded Protein Response.microPublication biology · 2021Article
- Neuronal AMPK coordinates mitochondrial energy sensing and hypoxia resistance in C. elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Organisms adapt to their environment through coordinated changes in mitochondrial function and metabolism. The mitochondrial protonmotive force (PMF) is an electrochemical gradient that powers ATP synthesis and adjusts metabolism to energetic demands via cellular signaling. It is unknown how or where transient PMF changes are sensed and signaled due to the lack of precise spatiotemporal control in vivo. We addressed this by expressing a light-activated proton pump in mitochondria to spatiotemporally "turn off" mitochondrial function through PMF dissipation in tissues with light. We applied our construct-mitochondria-OFF (mtOFF)-to understand how metabolic status impacts hypoxia resistance, a response that relies on mitochondrial function. Activation of mtOFF induced starvation-like behavior mediated by AMP-activated protein kinase (AMPK). We found prophylactic mtOFF activation increased survival following hypoxia, and that protection relied on neuronal AMPK. Our study links spatiotemporal control of mitochondrial PMF to cellular metabolic changes that mediate behavior and stress resistance.
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Registered trials
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