ArticleMagnetic resonance in medicine2021
Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains.
Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 19 citations in OpenAlex.
- Diffusion-MRI-Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Regional Changes in the Fetal Telencephalic Wall Diffusion Metrics Across Late Second and Third Trimesters.Human brain mapping · 2025Article
- Surface-based Analyses of Diffusional Kurtosis Imaging in Amyotrophic Lateral Sclerosis: Relationship with Onset Subtypes.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Machine-learning based prediction of future outcome using multimodal MRI during early childhood.Seminars in fetal & neonatal medicine · 2024Review
- Diffusion kurtosis imaging, MAP-MRI and NODDI selectively track gray matter myelin density in the primate cerebral cortex.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Disrupted white matter microstructure correlates with impulsivity in children and adolescents with bipolar disorder.Journal of psychiatric research · 2023Article
- Diffusional kurtosis imaging as a possible prognostic marker of cervical incomplete spinal cord injury outcome: a prospective pilot study.Acta neurochirurgica · 2022Article
- Rapid microstructural plasticity in the cortical semantic network following a short language learning session.PLoS biology · 2021Article
- Diffusional Kurtosis Imaging in the Diffusion Imaging in Python Project.Frontiers in human neuroscience · 2021Article
- Early neuroimaging and ultrastructural correlates of injury outcome after neonatal hypoxic-ischaemia.Brain communications · 2021Article
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4 authors at 2 institutions in 1 country.
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Abstract
purposeTo investigate the neuroanatomical underpinning of healthy macaque brain cortical microstructure measured by diffusion kurtosis imaging (DKI), which characterizes non-Gaussian water diffusion.
methodsHigh-resolution DKI was acquired from 6 postmortem macaque brains. Neurofilament density (ND) was quantified based on structure tensor from neurofilament histological images of a different macaque brain sample. After alignment of DKI-derived mean kurtosis (MK) maps to the histological images, MK and histology-based ND were measured at corresponding regions of interests characterized by distinguished cortical MK values in the prefrontal/precentral-postcentral and temporal cortices. Pearson correlation was performed to test significant correlation between these cortical MK and ND measurements.
resultsHeterogeneity of cortical MK across different cortical regions was revealed, with significantly and consistently higher MK measurements in the prefrontal/precentral-postcentral cortex compared to those in the temporal cortex across all six scanned macaque brains. Corresponding higher ND measurements in the prefrontal/precentral-postcentral cortex than in the temporal cortex were also found. The heterogeneity of cortical MK is associated with heterogeneity of histology-based ND measurements, with significant correlation between cortical MK and corresponding ND measurements (P < .005).
conclusionThese findings suggested that DKI-derived MK can potentially be an effective noninvasive biomarker quantifying underlying neuroanatomical complexity inside the cerebral cortical mantle for clinical and neuroscientific research.
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