Evidence map›Paper›PMID 33058141›Full record

ArticleClinical and experimental immunology2021

CD40L-stimulated B cells for ex-vivo expansion of polyspecific non-human primate regulatory T cells for translational studies.

P Alonso-Guallart, N Llore, E Lopes, S-B Kofman, S-H Ho, J Stern, G Pierre, K Bruestle, Q Tang, M Sykes and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical and experimental immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Decoding TNF receptor superfamily control of CD4Cell communication and signaling : CCS · 2026
    Review
  2. Expansion of B10 cellsInternational journal of molecular medicine · 2025
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

P Alonso-GuallartColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0002-8801-2457
N LloreColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
E LopesColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
S-B KofmanColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
S-H HoColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
J SternColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
G PierreColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
K BruestleColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Q TangDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
M SykesColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
A GriesemerColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Columbia University Irving Medical Center · USUniversity of California, San Francisco · US

Funding

Using Polyclonal Tregs to Develop a Compressed BMT Regiment for Deceased Donor Islets and KidneysU19AI131474 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2017 to 2022
$12.1M
Robust allograft tolerance in non-human primatesR01OD017949 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2015 to 2019
$4.5M
BD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600k
NIAID NIH HHS U19 AI131474NIH HHS R01 OD017949NIH HHS S10 OD020056
6 · The paper itself

Abstract

The therapeutic applications of regulatory T cells (T

Indexed as

AnimalsAntigen-Presenting CellsB-LymphocytesCD40 LigandCell Line, TumorCytokinesFlow CytometryForkhead Transcription FactorsHumansInflammationK562 CellsPrimatesT-Lymphocytes, RegulatoryCD40 LigandCytokinesForkhead Transcription FactorsCD40L-stimulated B cellsnon-human primatesregulatory T cellstolerance

Identifiers

PMID33058141
PMCPMC7874833
OpenAlexW3093236628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.