ArticleEuropean journal of applied physiology2021
Effects of acute and sub-acute hypobaric hypoxia on oxidative stress: a field study in the Alps.
Article in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Trial
- Systemic Oxy-Inflammatory, Hormonal, and Mood Responses to a Ski Mountaineering Competition: Preliminary Evidence from Military Athletes.Sports (Basel, Switzerland) · 2026Article
- Effects of extreme mountain ultramarathon on stress-related biomarkers from multiple biological matrices in adult male runners.Physiological reports · 2026Article
- Oxy-Inflammatory Profile of Finishers and No-Finishers in an Extreme Ultra-Endurance Trail Race: The 866 km Transpyrénéa.International journal of molecular sciences · 2026Article
- Ambiol Prevents Changes in the Functional Characteristics of Mitochondria Under Hypoxia.International journal of molecular sciences · 2026Article
- Low oxygen content as a potential risk factor for scoliosis: a school-based cross-sectional study.Frontiers in public health · 2026Article
- From Hypoxia to Oxidative Stress: Antioxidants' Role to Reduce Male Reproductive Damage.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Oxygen metabolism abnormalities and high-altitude cerebral edema.Frontiers in immunology · 2025Review
- High-altitude hypoxia exacerbates gastric mucosal damage and regulates the Nrf2 signaling pathway inFrontiers in physiology · 2025Article
- Research Progress on Using Nanoparticles to Enhance the Efficacy of Drug Therapy for Chronic Mountain Sickness.Pharmaceutics · 2024Review
- Decompression Illness After Technical Diving Session in Mediterranean Sea: Oxidative Stress, Inflammation, and HBO Therapy.International journal of molecular sciences · 2024Article
- Rapid altitude displacement induce zebrafish appearing acute high altitude illness symptoms.Heliyon · 2024Article
- Oxy-Inflammation in Humans during Underwater Activities.International journal of molecular sciences · 2024Review
- Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes.Metabolites · 2023Article
- Chelation Therapy Associated with Antioxidant Supplementation Can Decrease Oxidative Stress and Inflammation in Multiple Sclerosis: Preliminary Results.Antioxidants (Basel, Switzerland) · 2023Article
- Oxidative Stress Response Kinetics after 60 Minutes at Different Levels (10% or 15%) of Normobaric Hypoxia Exposure.International journal of molecular sciences · 2023Article
- Protective effects of the Terminalia bellirica tannin-induced Nrf2/HO-1 signaling pathway in rats with high-altitude pulmonary hypertension.BMC complementary medicine and therapies · 2023Article
- The "ON-OFF" Switching Response of Reactive Oxygen Species in Acute Normobaric Hypoxia: Preliminary Outcome.International journal of molecular sciences · 2023Article
- Occlusion preconditioned mice are resilient to hypobaric hypoxia-induced myocarditis and arrhythmias due to enhanced immunomodulation, metabolic homeostasis, and antioxidants defense.Frontiers in immunology · 2023Article
- The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion.Journal of biomedical research · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
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Abstract
purposeHigh altitude results in lower barometric pressure and hence partial pressure of O
methodsFourteen lowlander subjects (mean age 27.3 ± 5.9 years) were exposed to HH at 3269 m s.l. ROS production, related oxidative damage to cellular components, systemic inflammatory response and renal function were determined through blood and urine profile performed at 1st, 2nd, 4th, 7th, and 14th days during sojourn.
resultsKinetics of changes during HH exposition showed out significant (range p < 0.05-0.0001) increases that at max corresponds to 38% for ROS production rate, 140% for protein carbonyl, 44% for lipid peroxidation, 42% for DNA damage, 200% for inflammatory cytokines and modifications in renal function (assessed by neopterin concentration: 48%). Conversely, antioxidant capacity significantly (p < 0.0001) decreased - 17% at max.
conclusionThis 14 days in-field study describes changes of oxidative-stress biomarkers during HH exposure in lowlanders. The results show an overproduction of ROS and consequent oxidative damage to protein, lipids and DNA with a decrease in antioxidant capacity and the involvement of inflammatory status and a transient renal dysfunction. Exposure at high altitude induces a hypoxic condition during acute and sub-acute phases accompanied by molecular adaptation mechanism indicating acclimatization.
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