ArticleClinical oral investigations2021
Bacterial levels and amount of endotoxins in carious dentin within reversible pulpitis scenarios.
Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Efficacy of concentrated growth factor compared with other types of regenerative endodontic procedures: a systematic review.BMC oral health · 2025Pooled it
- The Impact of Fluoride Varnish Application on the Supragingival Plaque Microbiome in Preschoolers: A Dynamic Study.Current microbiology · 2025Article
- Tooth and Composite Discoloration After Photodynamic Therapy with Different Photosensitizers and Cleansers Under Accelerated Aging Conditions.Journal of lasers in medical sciences · 2025Article
- A deep learning feature importance test framework for integrating informative high-dimensional biomarkers to improve disease outcome prediction.Briefings in bioinformatics · 2024Article
- Comparison of the main pathogenic microorganisms of various common oral diseases in children and adults.Pediatric discovery · 2023Article
- In silico evaluation and selection of the best 16S rRNA gene primers for use in next-generation sequencing to detect oral bacteria and archaea.Microbiome · 2023Article
- Determination of the optimal concentration and duration of C5aR antagonist application in an inflammatory model of human dental pulp cells.FEBS open bio · 2023Article
- Chronic exposure to lipopolysaccharides as an in vitro model to simulate the impaired odontogenic potential of dental pulp cells under pulpitis conditions.Journal of applied oral science : revista FOB · 2023Article
- Overexpression of proinflammatory cytokines in dental pulp tissue and distinct bacterial microbiota in carious teeth of Mexican Individuals.Frontiers in cellular and infection microbiology · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesthe objective of the present exploratory study was to determine bacterial diversity and endotoxin levels in deep carious lesions of teeth presenting symptoms of reversible pulpitis. MATERIALS AND
methodsTwenty patients with deep carious lesions, reporting clinical symptomatology compatible with reversible pulpitis (n = 10) or not reporting clinical symptomatology (n = 10), were selected. Carious dentin samples were obtained with the aid of sterile and pyrogen-free spoon excavators and harvested in two steps: before and after infected dentin removal. Samples were collected for checkerboard and for kinetic chromogenic LAL assay for determination of microbial profile and quantitation of endotoxin, respectively. Data were analyzed by Mann Whitney for bacteria and two-way ANOVA for endotoxins (5%).
resultsNo difference on the studied bacteria was detected between the superficial and deep dentin layers. Symptomatic teeth showed greater presence of Lactobacillus species, Capnocytophaga sputigena, and Leptotrichia buccalis. For the endotoxins, symptomatic teeth resulted in greater quantity of endotoxins (p = 0.047), being 4.13 log
conclusionThe amount of the studied bacteria does not seem to be related to reported symptomatology of deep carious lesions, while endotoxins quantity is greater in symptomatic scenarios, regardless of the harvesting area. CLINICAL RELEVANCE: The understanding of bacterial amount in reversible pulpitis is important to establish a clinical protocol of treatment.
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