Evidence map›Paper›PMID 33057717›Full record

ArticleThe Journal of infectious diseases2021

An Outbreak of USA300 Methicillin-Resistant Staphylococcus aureus Among People With HIV in Japan.

Kazuhiko Ikeuchi, Eisuke Adachi, Takashi Sasaki, Masato Suzuki, Lay Ahyoung Lim, Makoto Saito, Michiko Koga, Takeya Tsutsumi, Yasutoshi Kido, Yuki Uehara and 1 more

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Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Kazuhiko IkeuchiIMSUT Hospital, The University of Tokyo, Minato-ku, Tokyo, Japan.
Eisuke AdachiIMSUT Hospital, The University of Tokyo, Minato-ku, Tokyo, Japan.
Takashi SasakiAnimal Research Center, Sapporo Medical University School of Medicine, Sapporo City, Hokkaido, Japan.
Masato SuzukiIMSUT Hospital, The University of Tokyo, Minato-ku, Tokyo, Japan.
Lay Ahyoung LimIMSUT Hospital, The University of Tokyo, Minato-ku, Tokyo, Japan.
Makoto SaitoIMSUT Hospital, The University of Tokyo, Minato-ku, Tokyo, Japan.
Michiko KogaIMSUT Hospital, The University of Tokyo, Minato-ku, Tokyo, Japan.
Takeya TsutsumiIMSUT Hospital, The University of Tokyo, Minato-ku, Tokyo, Japan.
Yasutoshi KidoOsaka City University, Abeno-ku, Osaka, Japan.
Yuki UeharaSt Luke's International Hospital, Chuo-ku, Tokyo, Japan.
Hiroshi YotsuyanagiIMSUT Hospital, The University of Tokyo, Minato-ku, Tokyo, Japan.
University of Tokyo Hospital · JPOsaka City University · JPSapporo Medical University · JPSt. Luke's International Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUSA300 produces Panton-Valentin leucocidin (PVL) and is known as a predominant community-associated methicillin-resistant Staphylococcus aureus (MRSA) strain in the United States, but it was extremely rare in Japan. We report here an outbreak of USA300 in people with HIV (PWH) in Tokyo, Japan.

methodsWe analyzed the cases of PVL-MRSA infection between 2010 and 2020 and screened for nasal colonization of PVL-MRSA in PWH who visited an HIV/AIDS referral hospital from December 2019 to March 2020. Whole-genome sequencing-based single nucleotide polymorphism (SNP) analysis was performed on these isolates.

resultsDuring the study period, a total of 21 PVL-MRSA infections in 14 patients were identified after 2014. The carriage prevalence was 4.3% (12/277) and PVL-MRSA carriers were more likely to have sexually transmitted infections (STIs) within a year compared with patients who had neither a history of PVL-MRSA infection nor colonization (33.3% [4/12] vs 10.1% [26/258]; P = .03). SNP analysis showed that all 26 isolates were ST8-SCCmecIVa-USA300. Twenty-four isolates were closely related (≤100 SNP differences) and had the nonsynonymous SNPs associated with carbohydrate metabolism and antimicrobial tolerance.

conclusionsAn outbreak of USA300 has been occurring among PWH in Tokyo and a history of STI was a risk of colonization.

Indexed as

Disease OutbreaksHomosexuality, MaleAdultAgedAged, 80 and overAnti-Bacterial AgentsCarrier StateDrug Resistance, Multiple, BacterialGenome, BacterialHIV InfectionsHumansMaleMethicillin-Resistant Staphylococcus aureusMiddle AgedMolecular TypingNoseAnti-Bacterial AgentsVirulence FactorsHIVmen who have sex with men (MSM)methicillin-resistant Staphylococcus aureus (MRSA)Panton-Valentine leucocidin (PVL)people with HIV (PWH)USA300

Identifiers

PMID33057717
OpenAlexW3092656237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.