Observational studyBlood advances2020
The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19.
Observational study in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it, 173 citations in OpenAlex.
- Systematic review and meta-analysis of the effect of ABO blood group on the risk of SARS-CoV-2 infection.PloS one · 2022Pooled it
- Association between ABO and Duffy blood types and circulating chemokines and cytokines.Genes and immunity · 2021Trial
- Association of ABO/Rh Blood Groups and ABO Gene VariantsViruses · 2026Article
- Association between ABO blood groups and clinical manifestations and outcomes of COVID-19: a retrospective cross-sectional study in southeast Iran.Scientific reports · 2026Article
- Association of ABO Blood Groups with Osteoporotic Hip Fracture Susceptibility in Chinese Adults.Calcified tissue international · 2025Article
- Do certain blood groups increase COVID-19 severity and mortality?Global epidemiology · 2025Article
- Association of HLA-B gene polymorphism and blood groups with COVID-19 susceptibility and severity.Scientific reports · 2025Article
- The Investigation of the Distribution of ABO/Rh Blood Group in Hospitalized COVID-19 Patients and Its Association With Disease Severity, Clinical Outcomes, Lab Tests, and Radiologic Findings.Health science reports · 2025Article
- Association between ABO blood group system and autoimmune liver disease.Frontiers in medicine · 2025Article
- ABO blood group and COVID-19 severity: Associations with endothelial and adipocyte activation in critically ill patients.PloS one · 2025Article
- Is ABO blood type a risk factor for adjacent segment degeneration after lumbar spine fusion?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Investigating ABO Blood Groups and Secretor Status in Relation to SARS-CoV-2 Infection and COVID-19 Severity.Journal of personalized medicine · 2024Review
- Correlation of ABO Blood Group Susceptibility to Disease Severity of SARS-COV-2: An Original Research.Journal of pharmacy & bioallied sciences · 2024Article
- Coronavirus infection and ABO blood grouping: Correlation or coincidence?Journal of family medicine and primary care · 2023Article
- Association Between Blood Groups and COVID-19 CT Severity: A Retrospective Analysis From a Tertiary Care Center.Cureus · 2023Article
- ABO blood group and rhesus factor association with inpatient COVID-19 mortality and severity: a two-year retrospective review.Blood research · 2023Article
- Risk Factors for Severe-Critical COVID-19 in Pregnant Women.Journal of clinical medicine · 2023Article
- Blood pressure pattern among blood donors exposed to SARS-CoV-2 in Luanda, Angola: A retrospective study.Health science reports · 2023Article
- Impact of ABO Blood Group, Hematological, and Biochemical Abnormalities on Incidence of Patients Infected with COVID-19.Archives of Razi Institute · 2023Article
- Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies on severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) suggest a protective effect of anti-A antibodies against viral cell entry that may hold relevance for SARS-CoV-2 infection. Therefore, we aimed to determine whether ABO blood groups are associated with different severities of COVID-19. We conducted a multicenter retrospective analysis and nested prospective observational substudy of critically ill patients with COVID-19. We collected data pertaining to age, sex, comorbidities, dates of symptom onset, hospital admission, intensive care unit (ICU) admission, mechanical ventilation, continuous renal replacement therapy (CRRT), standard laboratory parameters, and serum inflammatory cytokines. National (N = 398 671; P = .38) and provincial (n = 62 246; P = .60) ABO blood group distributions did not differ from our cohort (n = 95). A higher proportion of COVID-19 patients with blood group A or AB required mechanical ventilation (P = .02) and CRRT (P = .004) and had a longer ICU stay (P = .03) compared with patients with blood group O or B. Blood group A or AB also had an increased probability of requiring mechanical ventilation and CRRT after adjusting for age, sex, and presence of ≥1 comorbidity. Inflammatory cytokines did not differ between patients with blood group A or AB (n = 11) vs O or B (n = 14; P > .10 for all cytokines). Collectively, our data indicate that critically ill COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation, CRRT, and prolonged ICU admission compared with patients with blood group O or B. Further work is needed to understand the underlying mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.