ArticleNature2020
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
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- Systematic functional dissection of germline noncoding risk variants impacting clonal hematopoiesis.bioRxiv : the preprint server for biology · 2026Article
- Frequent and clinically relevant germline DNA repair gene variants in young and familial myeloproliferative neoplasms.Blood cancer journal · 2026Article
- Integrating genomic structural equation modeling and experimental validation to unravel the genetic basis of male genital lichen sclerosus.Frontiers in immunology · 2026Article
- Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation.Science (New York, N.Y.) · 2026Article
- Phenotypic risk factors linked to acute radiation-induced toxicities: a phenome-wide Mendelian randomization study of 12,042 cancer patients.Journal of Cancer · 2026Article
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- Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells.Nature cell biology · 2025Article
- 14,441 Genomics-Based Validated Automated Comprehensive Clinicopathologic Correlations for Myeloid Neoplasms.Scientific data · 2025Article
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- Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations.Nature communications · 2025Article
- Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase.Nature methods · 2025Article
- Mendelian Randomization-Based Discovery of Novel Protein Biomarkers and Drug Targets in Colorectal Cancer: Validation Through Prognostic Modeling, Single-Cell Analysis, and In Vitro Cell Experiments.Applied biochemistry and biotechnology · 2025Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors at 20 institutions in 7 countries.
Erik L Bao *Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6074-6766
Satish K Nandakumar *Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Xiaotian Liao *Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9715-270X
Alexander G BickBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Juha KarjalainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Marcin TabakaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Olga I GanPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Aki S HavulinnaInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Tuomo T J KiiskinenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-6306-8227
Caleb A LareauDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4179-4807
Aitzkoa L de Lapuente PortillaHematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Bo LiBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0668-1620
Connor EmdinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2385-8259
Veryan CoddDepartment of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.
Christopher P NelsonDepartment of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.ORCID http://orcid.org/0000-0001-8025-2897
Christopher J WalkerDepartment of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Claire ChurchhouseBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Albert de la ChapelleDepartment of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-9345-9248
Daryl E KleinDepartment of Pharmacology, Cancer Biology Institute, Yale University School of Medicine, West Haven, CT, USA.
Björn NilssonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Peter W F WilsonAtlanta VA Medical Center, Atlanta, GA, USA.
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Saiju PyarajanMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
J Michael GazianoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Nilesh J SamaniDepartment of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.
FinnGen
23andMe Research Team
Aviv RegevBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3293-3158
Aarno PalotieBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Benjamin M NealeBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1513-6077
John E DickPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Pradeep NatarajanBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8402-7435
Christopher J O'DonnellVA Boston Healthcare, Section of Cardiology, Boston, MA, USA.
Mark J DalyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Michael MilyavskyDepartment of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sekar KathiresanBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6724-032X
Vijay G SankaranDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. sankaran@broadinstitute.org.ORCID http://orcid.org/0000-0003-0044-443X
University of Helsinki · FIAbbVie (United States) · USBroad Institute · US23andMe (United States) · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USPfizer (United States) · USGlaxoSmithKline (United Kingdom) · GBHospital District of Helsinki and Uusimaa · FIFinnish Institute for Health and Welfare · FIBiogen (United States) · USNorthern Ostrobothnia Hospital District · FISanofi (France) · FRPirkanmaa Hospital District · FIVarsinais-Suomen Sairaanhoitopiiri · FIBorealis (Finland) · FIAstraZeneca (United Kingdom) · GBBusiness FinlandCentral Finland Health Care District · FIFinnish Red Cross · FITampere University · FI
Funding
Systematic Genetic Dissection of Human ErythropoiesisR01DK103794 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Vijay Ganesh Sankaran · 2014 to 2026
$5.9MNext generation functional genomics of hematology traitsR01HL146500 · NHLBI · UNIVERSITY OF WASHINGTON · PI ALEXANDER P REINER · 2020 to 2026
$5.7MTargeting Clonal Hematopoiesis of Indeterminate Potential Using Human GeneticsDP5OD029586 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BICK, ALEXANDER · 2020 to 2024
$2.3MBLRD VA I01 BX004821Howard Hughes Medical InstituteMedical Research Council MR/M012816/1NHLBI NIH HHS R01 HL146500NIDDK NIH HHS R01 DK103794NIH HHS DP5 OD029586
Abstract
Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the highest known for cancers
Indexed as
Cell LineageCell Self RenewalCheckpoint Kinase 2FemaleGenetic Predisposition to DiseaseHematopoietic Stem CellsHumansLeukocytesMaleMyeloproliferative DisordersNeoplasmsProto-Oncogene ProteinsRepressor ProteinsRiskTelomere HomeostasisCheckpoint Kinase 2CHEK2 protein, humanGFI1B protein, humanProto-Oncogene ProteinsRepressor Proteins
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.