ArticleNature2020
Cell-type-specific 3D epigenomes in the developing human cortex.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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97citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
What it found
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Who cites it
97 citing papers in PubMed, 162 citations in OpenAlex.
- Human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution.Nature communications · 2026Article
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- CCNB1IP1 regulatory evolution underlies gradual increases in cortical size and folding in primates.Nature genetics · 2026Article
- De novo structural variants in autism spectrum disorder disrupt distal regulatory interactions of neuronal genes.Genome research · 2026Article
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- Decoding 3D chromatin architecture reveals distinct enhancer classes underlying hierarchical gene regulation in prostate cancer.Genome biology · 2026Article
- Neural stem cell epigenomes and fate bias are temporally coordinated during mouse cortical development.Genes & development · 2026Article
- Genomic approaches for understanding the evolution of the human brain.Nature neuroscience · 2026Review
- 3D genetic architecture of schizophrenia risk across three neuronal subtypes.Molecular psychiatry · 2026Article
- FTO-mediated mActa pharmaceutica Sinica. B · 2026Article
- Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR.Nature biotechnology · 2026Article
- Predictive prioritization of enhancers associated with pancreatic disease risk.Cell genomics · 2026Article
- Neocortical neurogenesis: a proneural gene perspective.The FEBS journal · 2025Review
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- Super RNA Pol II domains enhance minor ZGA through 3D interaction to ensure the integrity of major transcriptional waves in late-ZGA mammals.Cell genomics · 2025Article
- Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development.Cell discovery · 2025Article
- Article
- Impact of chromatin on HIV-1 latency: a multi-dimensional perspective.Epigenetics & chromatin · 2025Review
- Integrative analysis of the 3D genome and epigenome in mouse embryonic tissues.Nature structural & molecular biology · 2025Article
- Examining the NEUROG2 lineage and associated gene expression in human cortical organoids.Development (Cambridge, England) · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 5 institutions in 1 country.
Michael Song *Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3355-4806
Mark-Phillip Pebworth *Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8224-9480
Xiaoyu Yang *Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Armen AbnousiDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.ORCID http://orcid.org/0000-0003-1822-0928
Changxu FanDepartment of Genetics, Washington University School of Medicine, St Louis, MO, USA.
Jia WenDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-3273-7704
Jonathan D RosenDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6396-4219
Mayank N K ChoudharyDepartment of Genetics, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-9824-7217
Xiekui CuiInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Ian R JonesInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Seth BergenholtzInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Ugomma C EzeThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8142-6318
Ivan JuricDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Bingkun LiInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6822-9440
Lenka MaliskovaInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7677-3833
Jerry LeeInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Weifang LiuDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Alex A PollenThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Yun LiDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-9275-4189
Ting WangDepartment of Genetics, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-6800-242X
Ming Hu *Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. hum@ccf.org.ORCID http://orcid.org/0000-0003-0987-2916
Arnold R KriegsteinThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA. arnold.kriegstein@ucsf.edu.ORCID http://orcid.org/0000-0001-5742-2990
Yin ShenInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. yin.shen@ucsf.edu.ORCID http://orcid.org/0000-0001-9901-5613
University of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USCleveland Clinic · USWashington University in St. Louis · USJames S. McDonnell Foundation · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MThe WashU-UCSC-EBI Human Genome Reference Center."U41HG010972 · NHGRI · WASHINGTON UNIVERSITY · PI Ira M Hall, Heng Li · 2019 to 2026
$24.9MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8MRapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8MGENCODE: comprehensive reference genome annotation for human and mouseU24HG007234 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI Fergal James Martin · 2021 to 2026
$16.1MDevelopment and Expansion of the Human Cerebral CortexR35NS097305 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRIEGSTEIN, ARNOLD · 2017 to 2024
$8.5MHigh throughput CRISPR-mediated functional validation of regulatory elementsUM1HG009402 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REN, BING, SHEN, YIN · 2017 to 2021
$8.4MPreclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL · 2013 to 2019
$8.0MPHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1MA Cellular Resolution Census of the Developing Human BrainU01MH114825 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ERIC J, KRIEGSTEIN, ARNOLD · 2017 to 2021
$6.7MTHE WASHU TARGET ENVIRONMENTAL EPIGENOMICS DATA COORDINATION CENTERU24ES026699 · NIEHS · WASHINGTON UNIVERSITY · PI WANG, TING · 2016 to 2021
$5.2MRESEARCH EDUCATION PROGRAM ON COMPUTATIONAL AND STATISTICAL TOOL DEVELOPMENT FOR ADDICTION GENETICSR25DA027995 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN, RICE, JOHN P. · 2009 to 2019
$4.3MNCI NIH HHS U01 CA200060NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY027789NHGRI NIH HHS R01 HG007175NHGRI NIH HHS R21 HG010065NHGRI NIH HHS U01 HG009391NHGRI NIH HHS U24 HG007234NHGRI NIH HHS U41 HG010972NHGRI NIH HHS UM1 HG009402NHLBI NIH HHS R01 HL129132NIA NIH HHS R01 AG057497NICHD NIH HHS U54 HD079124NIDA NIH HHS R25 DA027995NIDDK NIH HHS P30 DK063720NIEHS NIH HHS U24 ES026699NIGMS NIH HHS T32 GM007175NIGMS NIH HHS T32 GM007618NIH HHS S10 OD021822NIMH NIH HHS R01 MH106611NIMH NIH HHS U01 MH114825NINDS NIH HHS R35 NS097305
Abstract
Lineage-specific epigenomic changes during human corticogenesis have been difficult to study owing to challenges with sample availability and tissue heterogeneity. For example, previous studies using single-cell RNA sequencing identified at least 9 major cell types and up to 26 distinct subtypes in the dorsal cortex alone
Indexed as
EpigenomeEpigenomicsCell LineageCellsCells, CulturedCerebral CortexChromatinCRISPR-Cas SystemsDNA Transposable ElementsHistonesHumansImaging, Three-DimensionalMethylationMultifactorial InheritanceOrganogenesisPolymorphism, Single NucleotideChromatinDNA Transposable ElementsHistones
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