ArticleMolecular psychiatry2021
Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia.
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Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
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58citing papers in PubMed, 3 pooled it
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Musical rhythm abilities and risk for developmental speech-language problems and disorders: epidemiological and polygenic associations.Nature communications · 2025Pooled it
- Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities.Translational psychiatry · 2022Pooled it
- Language and reading impairments are associated with increased prevalence of non-right-handedness.Child developmentPooled it
- Electrophysiological Correlates of Familial Dyslexia in Two Siblings: A Case Report.Diagnostics (Basel, Switzerland) · 2026Article
- Heritable and experience-dependent cortical traits of reading ability.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Shared genetics between ADHD and reading/language abilities: Genome-wide correlations, stratified enrichment, cross-trait association, and mendelian randomization.JCPP advances · 2026Article
- Intergenerational transmission of the structure of the auditory cortex and reading skills.Developmental cognitive neuroscience · 2026Article
- Towards disentangling the polygenic contribution of dyslexia to school performance.Translational psychiatry · 2026Article
- Does bilingualism buffer genetic predispositions to reading difficulties through alterations of structural interhemispheric connectivity? An ABCDbioRxiv : the preprint server for biology · 2026Article
- Toward an Improved Understanding of Dyslexia: Reflections on a New Consensus Definition and Its Implications.Dyslexia (Chichester, England) · 2026Article
- From genes to networks: neurobiological bases of neurodiversity across common developmental disorders.Frontiers in neuroscience · 2026Review
- Translating the Power of Precision Medicine Into the World of Communication Disorders.Journal of speech, language, and hearing research : JSLHR · 2025Review
- Genomic Investigations of Spoken and Written Language Abilities: A Guide to Advances in Approaches, Technologies, and Discovery.Journal of speech, language, and hearing research : JSLHR · 2025Review
- Genetic Abnormalities in Neurodevelopmental Disorders with Multidimensional Impairment.Journal of molecular neuroscience : MN · 2025Article
- RETRACTED: Idea Density and Grammatical Complexity as Neurocognitive Markers.Brain sciences · 2025Review
- Mediational effects of reading-related intermediate phenotypes from polygenic scores to reading skills.NPJ science of learning · 2025Article
- Multivariate genome-wide association analysis of dyslexia and quantitative reading skill improves gene discovery.Translational psychiatry · 2025Article
- The role of self-compassion in adults with dyslexia.Annals of dyslexia · 2025Article
- Genetic advances in neurodevelopmental disorders.Medical review (2021) · 2025Review
- Genetic neurodevelopmental clustering and dyslexia.Molecular psychiatry · 2025Article
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Authors and funding
49 authors at 20 institutions in 13 countries.
Alessandro GialluisiDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0002-7388-4463
Till F M Andlauer *Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0002-2917-5889
Nazanin Mirza-Schreiber *Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0003-0836-8267
Kristina Moll *Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig-Maximilians University, Munich, Germany.
Jessica BeckerDepartment of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.
Per HoffmannDepartment of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-6573-983X
Kerstin U LudwigDepartment of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-8541-2519
Darina CzamaraDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0001-7381-904X
Beate St PourcainLanguage and Genetics Department, Max Planck Institute for Psycholinguistics and Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-4680-3517
Ferenc HonbolygóBrain Imaging Centre, Research Centre of Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary.
Dénes TóthBrain Imaging Centre, Research Centre of Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary.
Valéria CsépeBrain Imaging Centre, Research Centre of Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary.
Guillaume HuguetHuman Genetics and Cognitive Functions Unit, Institut Pasteur and University Paris Diderot, Sorbonne Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-4746-6030
Yves ChaixToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France.
Stephanie IannuzziChildren's Hospital, Purpan University Hospital, Toulouse, France.
Jean-Francois DemonetLeenaards Memory Centre, Department of Clinical Neurosciences Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland.
Andrew P MorrisDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Jacqueline HulslanderInstitute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Erik G WillcuttInstitute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
John C DeFriesInstitute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Richard K OlsonInstitute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Shelley D SmithDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
Bruce F PenningtonDevelopmental Neuropsychology Lab and Clinic, Department of Psychology, University of Denver, Denver, CO, USA.
Anniek VaessenDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience and Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, The Netherlands.
Urs MaurerDepartment of Psychology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.ORCID http://orcid.org/0000-0002-4156-8597
Heikki LyytinenCentre for Research on Learning and Teaching, Department of Psychology, University of Jyväskylä, Jyväskylä, Finland.
Myriam Peyrard-JanvidDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Paavo H T LeppänenCentre for Research on Learning and Teaching, Department of Psychology, University of Jyväskylä, Jyväskylä, Finland.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Milene BonteDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience and Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, The Netherlands.
John F SteinDepartment of Physiology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5843-8986
Joel B TalcottSchool of Life and Health Sciences, Aston University, Birmingham, UK.ORCID http://orcid.org/0000-0001-7958-8369
Fabien FauchereauHuman Genetics and Cognitive Functions Unit, Institut Pasteur and University Paris Diderot, Sorbonne Paris Cité, Paris, France.
Arndt WilckeCognitive Genetics Unit, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
Holger KirstenCognitive Genetics Unit, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.ORCID http://orcid.org/0000-0002-3126-7950
Bent MüllerCognitive Genetics Unit, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
Clyde FrancksLanguage and Genetics Department, Max Planck Institute for Psycholinguistics and Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-9098-890X
Thomas BourgeronHuman Genetics and Cognitive Functions Unit, Institut Pasteur and University Paris Diderot, Sorbonne Paris Cité, Paris, France.
Anthony P MonacoWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7480-3197
Franck RamusLaboratoire de Sciences Cognitives et Psycholinguistique, Ecole Normale Supérieure, CNRS, EHESS, PSL University, Paris, France.ORCID http://orcid.org/0000-0002-1122-5913
Karin LanderlInstitute of Psychology, University of Graz and BioTechMed, Graz, Austria.
Juha KereDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0003-1974-0271
Thomas S ScerriWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Silvia ParacchiniSchool of Medicine, University of St Andrews, St Andrews, UK.ORCID http://orcid.org/0000-0001-9934-8602
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics and Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-3132-1996
Johannes Schumacher *Department of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.
Markus M Nöthen *Department of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.
Bertram Müller-Myhsok *Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. bmm@psych.mpg.de.
Gerd Schulte-Körne *Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig-Maximilians University, Munich, Germany. Gerd.Schulte-Koerne@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-9960-1572
University of Bonn · DEUniversity of Colorado Boulder · USFraunhofer Institute for Cell Therapy and Immunology · DEHungarian Academy of Sciences · HUInstitut Pasteur · FRRadboud University Nijmegen · NLCentre for Human Genetics · GBLudwig-Maximilians-Universität München · DEMaastricht University · NLUniversity of Jyväskylä · FIAston University · GBBioTechMed-Graz · ATCentre Hospitalier Universitaire de Toulouse · FRCentre National de la Recherche Scientifique · FRChinese University of Hong Kong · HKHelmholtz Zentrum München · DEIstituto Neurologico Mediterraneo · ITKarolinska Institutet · SEMax Planck Institute of Psychiatry · DETufts University · US
Funding
VALIDITY OF SUBTYPES OF ADHDP50HD027802 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI ERIK G WILLCUTT · 1990 to 2026
$44.9MEtiology of Reading Disabilities and Comorbid ADHDR01HD047264 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI WILLCUTT, ERIK G · 2005 to 2009
$2.7MNICHD NIH HHS P50 HD027802NICHD NIH HHS R01 HD047264Wellcome TrustWellcome Trust 076113
Abstract
Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40-60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also calculated polygenic scores (PGSs) based on large-scale GWAS data for different neuropsychiatric disorders and cortical brain measures, educational attainment, and fluid intelligence, testing them for association with dyslexia status in our sample. We observed statistically significant (p < 2.8 × 10
Indexed as
DyslexiaMultifactorial InheritancePolymorphism, Single NucleotideAttention Deficit Disorder with HyperactivityGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIntracellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsVEPH1 protein, human
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