Evidence map›Paper›PMID 33057157›Full record

ArticleScientific reports2020

Elevated perfusate [Na

D Ryan King, Rachel L Padget, Justin Perry, Gregory Hoeker, James W Smyth, David A Brown, Steven Poelzing

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Hypernatremia and intercalated disc edema synergistically exacerbate long-QT syndrome type 3 phenotype.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

D Ryan KingTranslational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Rachel L PadgetTranslational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Justin PerryDepartment of Human Nutrition, Virginia Polytechnic Institute and State University, Foods, and Exercise, Blacksburg, VA, USA.
Gregory HoekerCenter for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, 24016, USA.
James W SmythCenter for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, 24016, USA.
David A BrownDepartment of Human Nutrition, Virginia Polytechnic Institute and State University, Foods, and Exercise, Blacksburg, VA, USA.
Steven PoelzingTranslational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. poelzing@vtc.vt.edu.
Virginia Tech · USBiomedical Research Institute · US

Funding

Role of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9M
Signaling in Inherited and Acquired Sodium Channel Gain of FunctionR01HL138003 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN, WEINBERG, SETH HOWARD · 2018 to 2021
$2.6M
Translation initiation in cardiac intercellular communication and stress-induced remodelingR01HL132236 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SMYTH, JAMES WILLIAM · 2017 to 2021
$2.0M
The Role of the Sodium Channel Beta Subunit in Cardiac ConductionR01HL141855 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G, POELZING, STEVEN · 2018 to 2021
$1.8M
Mitochondrial respirasomes in acute coronary syndromesR01HL123647 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI HULVER, MATTHEW W, SHAIKH, SAAME R · 2015 to 2018
$1.4M
Hypernatremic perfusion decreases mechanical and mitochondrial recovery following an ischemic insultF31HL147438 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KING, DAVID RYAN · 2019 to 2020
$67k
NHLBI NIH HHS F31 HL147438NHLBI NIH HHS R01 HL102298NHLBI NIH HHS R01 HL123647NHLBI NIH HHS R01 HL132236NHLBI NIH HHS R01 HL138003NHLBI NIH HHS R01 HL141855
6 · The paper itself

Abstract

Recent studies revealed that relatively small changes in perfusate sodium ([Na

Indexed as

AnimalsHeartHumansMaleMyocardial ContractionMyocardial IschemiaMyocardiumRatsRats, Sprague-DawleyReperfusionSodiumSodium-Calcium ExchangerSodiumSodium-Calcium Exchanger

Identifiers

PMID33057157
PMCPMC7560862
OpenAlexW3093008124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.