ArticleScientific reports2020
The structural role of osteocalcin in bone biomechanics and its alteration in Type-2 Diabetes.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Molecular-level understanding of the aging bone and regeneration mechanisms using computational methods.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Diabetic bone fragility through advanced glycation end product-collagen axis: Mechanisms and therapy of sodium glucose cotransporter 2 inhibitors.World journal of diabetes · 2025Review
- Local mapping of the nanoscale viscoelastic properties of fluid membranes by AFM nanorheology.Nature communications · 2025Article
- Review
- Effect of BaWorld journal of microbiology & biotechnology · 2024Article
- Bioinformatics study of phytase from Aspergillus niger for use as feed additive in livestock feed.Journal, genetic engineering & biotechnology · 2023Article
- Structural role of osteocalcin and its modification in bone fracture.Applied physics reviews · 2023Article
- A coarse-grained molecular dynamics investigation of the role of mineral arrangement on the mechanical properties of mineralized collagen fibrils.Journal of the Royal Society, Interface · 2023Article
- Energy dissipation of osteopontin at a HAp mineral interface: Implications for bone biomechanics.Biophysical journal · 2022Article
- Controlled Formation of Carboxymethyllysine in Bone Matrix through Designed Glycation Reaction.JBMR plus · 2021Article
- Poor bone matrix quality: What can be done about it?Current osteoporosis reports · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study presents an investigation into the role of Osteocalcin (OC) on bone biomechanics, with the results demonstrating that the protein's α-helix structures play a critical role in energy dissipation behavior in healthy conditions. In the first instance, α-helix structures have high affinity with the Hydroxyapatite (HAp) mineral surface and provide favorable conditions for adsorption of OC proteins onto the mineral surface. Using steered molecular dynamics simulation, several key energy dissipation mechanisms associated with α-helix structures were observed, which included stick-slip behavior, a sacrificial bond mechanism and a favorable binding feature provided by the Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.