ArticleScientific reports2020
Design and in vivo evaluation of a microparticulate depot formulation of buprenorphine for veterinary use.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Evaluation of a human slow-release buprenorphine formulation in rats - tactile sensitivity and plasma concentration.Laboratory animal research · 2026Article
- Carprofen and buprenorphine delivery using micropipette-guided drug administration (MDA) in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Current practices of pain assessment and analgesic use in laboratory mice: A 2022 FELASA Working Group survey.Laboratory animals · 2025Article
- Unveiling the Future: Opportunities in Long-Acting Injectable Drug Development for Veterinary Care.Pharmaceutics · 2025Review
- Refining pain management in mice by comparing multimodal analgesia and NSAID monotherapy for neurosurgical procedures.Scientific reports · 2024Article
- Development of opioid analgesic tolerance in rat to extended-release buprenorphine formulated for laboratory subjects.PloS one · 2024Article
- Long-Acting Opioid Analgesics for Acute Pain: Pharmacokinetic Evidence Reviewed.Veterinary sciences · 2023Review
- A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models.Scientific reports · 2023Article
- Severity Assessment in Rats Undergoing Subarachnoid Hemorrhage Induction by Endovascular Perforation or Corresponding Sham Surgery.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Buprenorphine is a frequently used analgetic agent in veterinary medicine. A major drawback, however, is the short duration of action requiring several daily administrations. We therefore designed a poly-lactic-co-glycolic acid (PLGA) based microparticulate drug formulation for sustained parenteral drug release. Particles were designed to allow for a fast onset of action and a duration of the analgesic effect of at least two days in laboratory mice. Microparticles were produced using a solvent evaporation technique. Release rate was dependent on polymer type and particle size. Spherical particles used for subsequent animal studies had a mean size of 50 µm and contained 4.5% of buprenorphine. Drug release was characterized by an initial burst release of 30% followed by complete release over seven days. In vivo pharmacokinetic experiments in female C57BL/6 J mice confirmed prolonged exposure in plasma and brain tissue and correlated with the pharmacological effect in the hot plate assay or after minor abdominal surgery. No adverse side effects with respect to food and water intake, body weight, local tolerability, or nesting behavior were observed. Our formulation is an attractive alternative to established immediate release formulations. A use for prolonged pain management in laboratory animals is proposed.
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