ArticleScientific reports2020
Toward an effective use of laser-driven very high energy electrons for radiotherapy: Feasibility assessment of multi-field and intensity modulation irradiation schemes.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Beyond apoptosis: nanomedicine enabled reprogramming of tumor cell death for next-generation radiosensitization.Journal of nanobiotechnology · 2026Review
- Start-to-end modelling of laser-plasma acceleration, beam transport and dose deposition of very high-energy electrons for radiotherapy.Scientific reports · 2026Article
- Highly ordered vertical nickel nanotubes and nanowires on thin substrate for high power lasers experiments.Discover nano · 2025Article
- Numerical study of self-injected electron acceleration in CNT structured targets driven by an 800 nm laser.Scientific reports · 2025Article
- Ultra-high-brightness and tuneable attosecond-long electron beams with the laser wake field acceleration.Scientific reports · 2025Article
- Integrated optoelectronic fiber for transurethral surgery with simultaneous laser and electrovaporization.Scientific reports · 2025Article
- Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype.Nature communications · 2025Article
- Probing Spatiotemporal Effects of Intertrack Recombination with a New Implementation of Simultaneous Multiple Tracks in TRAX-CHEM.International journal of molecular sciences · 2025Article
- Review
- Mechanisms of the FLASH effect: current insights and advances.Frontiers in cell and developmental biology · 2025Review
- Morphofunctional Features of Glomeruli and Nephrons After Exposure to Electrons at Different Doses: Oxidative Stress, Inflammation, Apoptosis.Current issues in molecular biology · 2024Article
- Treatment planning for very high energy electrons: Studies that indicate the potential of the modality.Physics and imaging in radiation oncology · 2024Review
- First in vitro cell co-culture experiments using laser-induced high-energy electron FLASH irradiation for the development of anti-cancer therapeutic strategies.Scientific reports · 2024Article
- Changes in Telomere Length in Leukocytes and Leukemic Cells after Ultrashort Electron Beam Radiation.International journal of molecular sciences · 2024Article
- FLASH Radiotherapy: Expectations, Challenges, and Current Knowledge.International journal of molecular sciences · 2024Review
- Extending deterministic transport capabilities for very-high and ultra-high energy electron beams.Scientific reports · 2024Article
- Chaotic dynamics in X-ray free-electron lasers with an optical undulator.Scientific reports · 2024Article
- Transformative Technology for FLASH Radiation Therapy.Applied sciences (Basel, Switzerland) · 2023Article
- Efficient plasma electron accelerator driven by linearly chirped multi-10-TW laser pulses.Scientific reports · 2023Article
- Determination of the ion collection efficiency of the Razor Nano Chamber for ultra-high dose-rate electron beams.Medical physics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy with very high energy electrons has been investigated for a couple of decades as an effective approach to improve dose distribution compared to conventional photon-based radiotherapy, with the recent intriguing potential of high dose-rate irradiation. Its practical application to treatment has been hindered by the lack of hospital-scale accelerators. High-gradient laser-plasma accelerators (LPA) have been proposed as a possible platform, but no experiments so far have explored the feasibility of a clinical use of this concept. We show the results of an experimental study aimed at assessing dose deposition for deep seated tumours using advanced irradiation schemes with an existing LPA source. Measurements show control of localized dose deposition and modulation, suitable to target a volume at depths in the range from 5 to 10 cm with mm resolution. The dose delivered to the target was up to 1.6 Gy, delivered with few hundreds of shots, limited by secondary components of the LPA accelerator. Measurements suggest that therapeutic doses within localized volumes can already be obtained with existing LPA technology, calling for dedicated pre-clinical studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.