Evidence map›Paper›PMID 33057074›Full record

ArticleScientific reports2020

Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis.

Heike C Hawerkamp, Lasse van Geelen, Jan Korte, Jeremy Di Domizio, Marc Swidergall, Afaque A Momin, Francisco J Guzmán-Vega, Stefan T Arold, Joachim Ernst, Michel Gilliet and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. EliminateJournal of medical microbiology · 2026
    Article
  3. Article
  4. Review
  5. Multifaceted Roles of IL-26 in Physiological and Pathological Conditions.International journal of molecular sciences · 2025
    Review
  6. iScience · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Frontiers in cellular and infection microbiology · 2023
    Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Heike C HawerkampDepartment of Dermatology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.ORCID 0000-0002-3990-8230
Lasse van GeelenDepartment of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Düsseldorf, Germany.ORCID 0000-0003-3879-4136
Jan KorteDepartment of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Düsseldorf, Germany.
Jeremy Di DomizioDepartment of Dermatology, University Hospital CHUV, Lausanne, Switzerland.ORCID 0000-0002-6281-3918
Marc SwidergallDepartment of Biology, Molecular Mycology, Heinrich-Heine-University, Düsseldorf, Germany.ORCID 0000-0002-5261-6267
Afaque A MominDivision of Biological and Environmental Sciences and Engineering (BESE), Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.ORCID 0000-0002-5058-9445
Francisco J Guzmán-VegaDivision of Biological and Environmental Sciences and Engineering (BESE), Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Stefan T AroldDivision of Biological and Environmental Sciences and Engineering (BESE), Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.ORCID 0000-0001-5278-0668
Joachim ErnstDepartment of Biology, Molecular Mycology, Heinrich-Heine-University, Düsseldorf, Germany.
Michel GillietDepartment of Dermatology, University Hospital CHUV, Lausanne, Switzerland.ORCID 0000-0002-4609-3762
Rainer KalscheuerDepartment of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Düsseldorf, Germany.
Bernhard HomeyDepartment of Dermatology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Stephan MellerDepartment of Dermatology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. Stephan.Meller@uni-duesseldorf.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis-causing Mycobacterium tuberculosis (Mtb) is transmitted via airborne droplets followed by a primary infection of macrophages and dendritic cells. During the activation of host defence mechanisms also neutrophils and T helper 1 (T

Indexed as

AdultAgedCell LineCytokinesDendritic CellsFemaleHEK293 CellsHumansInterleukinsLeukocytes, MononuclearMacrophagesMaleMiddle AgedMycobacterium tuberculosisRNA, MessengerTHP-1 CellsCytokinesIL26 protein, humanInterleukinsRNA, MessengerTumor Necrosis Factor-alpha

Identifiers

PMID33057074
PMCPMC7558018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.